FREQUENCY OF HEPATITIS C SEROCONVERSION IN CHRONIC KIDNEY DISEASE PATIENTS ON HEMODIALYSIS

Authors

  • Muhammad Nadeem Qureshi Medical Specialist, Health Department, Khyber Pakhtunkhwa, Pakistan
  • Affan Ali, Syed Department of Medicine, Abbottabad International Medical College, Abbottabad, Pakistan
  • Sumera Kazmi Department of Medicine, Abbottabad International Medical College, Abbottabad, Pakistan
  • Javed Iqbal Khan Surgical Unit, Type D Hospital, Havelian, Pakistan
  • Mir Jalal ud Din Department of Medicine, Women Medical College, Abbottabad, Pakistan
  • Isma Waheed Benazir Bhutto Shaheed Teaching Hospital, Abbottabad, Pakistan

Keywords:

Hepatitis C, Chronic Kidney Disease, Haemodialysis, Seroconversion, Renal replacement therapy

Abstract

Background: Haemodialysis increases Hepatitis-C seroconversion risk adversely affecting Chronic Kidney Disease (CKD) prognosis. This study aimed to determine the frequency of Hepatitis C seroconversion in chronic kidney disease patients on haemodialysis. Method: This cross-sectional study was conducted at Dialysis Unit of Ayub Teaching Hospital, Abbottabad from March 2016 to January 2019. A pre-designed proforma was used for data collection. A sample of 121 patients of dialysis dependent CKD was enrolled for the study through non-probability consecutive sampling. The Glomerular Filtration Rate (GFR) was re-estimated from serum creatinine to confirm the diagnosis using Modification of Diet in Renal Disease (MDRD) study equation. Patients who were Hepatitis C virus (HCV) negative at the start of dialysis, and became positive 3 months post-dialysis were considered having undergone seroconversion. Data were analysed using SPSS-16. Results: Out of 121 participants, 80 (66.1%) were male and 41 (33.8%) were female. The mean age of the patients was 51.0±6.22 years with range from 41 to 61 years. Hepatitis C seropositivity was recorded in 40 (33.06%) of the study participants during the study period. Statistically significant (p<0.05) associations were observed between HCV seropositivity and age and gender of the patients. Conclusion: Hepatitis C infection is a common complication of haemodialysis. Rigorous screening of patients for Hepatitis C and separate machines for Hepatitis C patients can lead to a decrease in the burden of this disease.

Pak J Physiol 2023;19(2):32–5

Downloads

Download data is not yet available.

Author Biographies

Muhammad Nadeem Qureshi, Medical Specialist, Health Department, Khyber Pakhtunkhwa, Pakistan

Medical Specialist, Type D Hospital Havelian, Pakistan

Affan Ali, Syed, Department of Medicine, Abbottabad International Medical College, Abbottabad, Pakistan

Assisstant Professor of Medicine, Abbottabad International Medical College, Abbottabad, Pakistan

Sumera Kazmi, Department of Medicine, Abbottabad International Medical College, Abbottabad, Pakistan

Associate Professor of Medicine, Abbottabad International Medical College, Abbottabad, Pakistan

Mir Jalal ud Din, Department of Medicine, Women Medical College, Abbottabad, Pakistan

Associate Professor of Medicine, Women Medical College, Abbottabad, Pakistan

Isma Waheed, Benazir Bhutto Shaheed Teaching Hospital, Abbottabad, Pakistan

Women Medical Officer, Benazir Bhutto Shaheed Teaching Hospital, Abbottabad, Pakistan

Downloads

Published

30-06-2023

How to Cite

1.
Qureshi MN, Ali A, Kazmi S, Khan JI, Jalal ud Din M, Waheed I. FREQUENCY OF HEPATITIS C SEROCONVERSION IN CHRONIC KIDNEY DISEASE PATIENTS ON HEMODIALYSIS. Pak J Phsyiol [Internet]. 2023 Jun. 30 [cited 2024 Jun. 24];19(2):32-5. Available from: https://pjp.pps.org.pk/index.php/PJP/article/view/1418