PROGNOSTIC SIGNIFICANCE OF TUMOUR THROMBUS CONSISTENCY ON CANCER-SPECIFIC SURVIVAL IN RENAL CELL CARCINOMA PATIENTS

Abstract

Background: Different studies have focused upon patients suffering from renal cell carcinoma (RCC) with inferior vena cava tumour thrombus. One biotic feature of renal RCC is venous system invasion. Both renal vein and inferior vena cava may be involved. The aim of current study was to evaluate the prognostic significance of the extent of thrombus in renal cell carcinoma patients with involvement of inferior vena cava. Methods: A total of 413 individuals were recruited in the study. All collected data were analysed retrospectively. Radical nephrectomy along with tumour thrombectomy was performed in all the participants. The pathological specimens were analysed for morphological feature, i.e., solid vs friable thrombus. To established clinicopathological predictor, Kaplan-Meier estimate and Cox regression analyses were done. Results: Friable and solid venous tumour thrombus (VTT) were found in 188 (46%) and 225 (54%) patients, respectively. For solid VTT, the Median Cancer Specific Survival (CSS) was 50 months while for friable VTT, the median CSS was 45 months. Thrombus consistency had no significant association with clinical features such as metastatic spread, pathological stage, perinephric fat invasion, and higher Fuhrman grade. Both survival analysis and Cox regression failed to be considered as a prognostic marker for CSS. Conclusion: Thrombus consistency appears not to be independently associated with survival in patients suffering from RCC.