ROLE OF TOBACCO SMOKING IN CAUSING HYPOMAGNESEMIA AND RHEUMATOID ARTHRITIS

Authors

  • Shahid Fareed Accident and Emergency Department, Lady Reading Hospital, Peshawar, Pakistan
  • Shah Hussain Accident and Emergency Department, Lady Reading Hospital, Peshawar, Pakistan
  • Shahida Batool Department of Pharmacology, Peshawar Medical College, Peshawar, Pakistan
  • Asma Amir Department of Anatomy, Peshawar Medical College, Peshawar, Pakistan
  • Nayab Khattak Department of Anatomy, Peshawar Medical College, Peshawar, Pakistan
  • Mohsin Ali Muhammad College of Medicine, Peshawar, Pakistan

Keywords:

Rheumatoid arthritis, hypomagnesemia, smoking, risk factor

Abstract

Rheumatoid arthritis (RA) is a type of immune system disorders that badly affect patient’s quality of life. The onset of disease constitutes a complex pathological process, and several mechanisms and triggers are proposed in the development of this disease. Magnesium (Mg) is an important trace element that plays a role in normal functioning of immune system. The deficiency of magnesium is found to be related to abnormal T-cells functions leading to secretion of pro-inflammatory chemicals such as interleukin-1 (IL-1), interleukin-6 (IL-6), tumour necrosis factor alpha (TNF-?) and histamine. Similarly, hypomagnesaemia also causes an increase in intracellular calcium level that leads to hyperactivation of phagocytes which are the first line of defence of our immune system. Tobacco smoking is a cause of hypomagnesemia in susceptible patients. The association between tobacco smoking and onset of rheumatoid arthritis is statistically significant in those who are smoking, even for less than 10 years.

Pak J Physiol 2021;17(2):46–50

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Published

30-06-2021

How to Cite

1.
Fareed S, Hussain S, Batool S, Amir A, Khattak N, Ali M. ROLE OF TOBACCO SMOKING IN CAUSING HYPOMAGNESEMIA AND RHEUMATOID ARTHRITIS. Pak J Phsyiol [Internet]. 2021 Jun. 30 [cited 2024 Apr. 19];17(2):46-50. Available from: https://pjp.pps.org.pk/index.php/PJP/article/view/1331

Issue

Vol. 17 No. 2 (2021): Pakistan Journal of Physiology

Section

Review Article

License

Pakistan Journal of Physiology, Pak J Physiol, PJP is FREE for research and academic purposes. It can be freely downloaded and stored, printed, presented, cited and quoted with full reference of, and acknowledgement to the PJP.