COMPARISON OF DIET INDUCED METABOLIC SYNDROME WITH ARTIFICIALLY INDUCED METABOLIC SYNDROME IN A RAT MODEL

Authors

  • Jawaria Ilyas Department of Physiology, Postgraduate Medical Institute/Ameer ud Din Medical College, Lahore, Pakistan
  • Noor Zahra Tehsil Headquarter Hospital, Sangla Hill, Nankana Sahib, Pakistan
  • Amer Hassan Siddique Department of Pharmacology, Postgraduate Medical Institute/Ameer ud Din Medical College, Lahore, Pakistan
  • Komal Iqbal Department of Physiology, Postgraduate Medical Institute/Ameer ud Din Medical College, Lahore, Pakistan
  • Rana Muhammad Yousaf Department of Physiology, Postgraduate Medical Institute/Ameer ud Din Medical College, Lahore, Pakistan
  • Muniza Saeed Department of Physiology, Postgraduate Medical Institute/Ameer ud Din Medical College, Lahore, Pakistan

DOI:

https://doi.org/10.69656/pjp.v18i2.1330

Keywords:

Metabolic syndrome, High fat high carbohydrate diet, Monosodium glutamate, Obesity, Hypertension, Dyslipidemia, Insulin resistance, Male SD rats

Abstract

Background: Metabolic syndrome is an emerging health problem. The diets rich in fats and refined carbohydrates and monosodium glutamate are considered major risk factors for this emerging epidemic. The aim of this study was to determine whether high fat high carbohydrate (HFHC) diet, Monosodium glutamate (MSG) diet or their combination is faster/more potent inducer of MS. Methods: Twenty male Sprague Dawley rats were randomly divided into four groups. Group 1 was given normal rat chow, group 2 was given HFHC diet, group 3 was given MSG in diet and group 4 was given both HFHC and MSG in their diet for 20 weeks. Body weight, blood pressure, lipid profile and glycaemic indices were determined at the end of study. Results: After 20 weeks of study, HFHC and MSG groups showed full blown Metabolic syndrome (MS) with development of obesity, hypertension, hyperglycaemia and dyslipidemia. However, group 4 which was given combination diet did not develop features of MS. Conclusion: Both HFHC and MSG containing diets when given alone are potent inducers of MS in rat model rather than their combination.

Pak J Physiol 2022;18(2):6?9

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Published

30-06-2022

How to Cite

1.
Ilyas J, Zahra N, Siddique AH, Iqbal K, Yousaf RM, Saeed M. COMPARISON OF DIET INDUCED METABOLIC SYNDROME WITH ARTIFICIALLY INDUCED METABOLIC SYNDROME IN A RAT MODEL. Pak J Phsyiol [Internet]. 2022 Jun. 30 [cited 2024 Dec. 3];18(2):6-9. Available from: https://pjp.pps.org.pk/index.php/PJP/article/view/1330

Issue

Vol. 18 No. 2 (2022): Pakistan Journal of Physiology

Section

Original Article

License

Pakistan Journal of Physiology, Pak J Physiol, PJP is FREE for research and academic purposes. It can be freely downloaded and stored, printed, presented, projected, cited and quoted with full reference of, and acknowledgement to the author(s) and the PJP. The contents are published with an international CC-BY-ND-4.0 License.