Trimester specific reference ranges of serum TSH, FT3 and FT4 during last trimester of pregnancy

Authors

  • Abdul Rehman Khokhar Ghazi Khan Medical College, Dera Ghazi Khan, Pakistan
  • Abdul Majeed Cheema Institute of Molecular Biology and Biotechnology, University of Lahore, Pakistan

DOI:

https://doi.org/10.69656/pjp.v17i1.1278

Keywords:

Thyroid hormones, Prewgnancy, Pakistan, Women, Reference vcalues, Trimester specific

Abstract

Background: Pregnancy is a stress for thyroid gland. After decades of research it is recommended that normal reference ranges of thyroid hormones test during different phases of pregnancy are necessary. The objective of this study was to establish serum TSH, FT3 and FT4 levels during last trimester of pregnancy. Methods: This was a cross-sectional analytical study. Simple convenient sampling technique was applied and sample size was calculated using classical sample size calculation formula of Cochran. Serum TSH, FT3 and FT4 were estimated by ELIZA method. Results: Maternal group showed serum TSH levels of 1.79±0.85 mIU/L. Maternal serum FT3 levels were 1.711±2.089 pmol/L. Mean serum FT4 of Maternal group were 1.31±1.07 ng/dL, (Range: 0.78–5.20 ng/dl). Conclusion: Our study population trimester specific ranges of TSH, FT4 and FT3 were lower than latest international levels according to Guidelines of American Thyroid Association of 2017. These values may be used to compare thyroid dysfunction in pregnancy.

Pak J Physiol 2021;17(1):

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Author Biography

Abdul Majeed Cheema, Institute of Molecular Biology and Biotechnology, University of Lahore, Pakistan

Department of Physiology

IMBB, University of Lahore

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Published

31-03-2021

How to Cite

1.
Khokhar AR, Cheema AM. Trimester specific reference ranges of serum TSH, FT3 and FT4 during last trimester of pregnancy. Pak J Phsyiol [Internet]. 2021 Mar. 31 [cited 2024 Dec. 22];17(1):19-22. Available from: https://pjp.pps.org.pk/index.php/PJP/article/view/1278

Issue

Vol. 17 No. 1 (2021): Pakistan Journal of Physiology

Section

Original Article

License

Pakistan Journal of Physiology, Pak J Physiol, PJP is FREE for research and academic purposes. It can be freely downloaded and stored, printed, presented, projected, cited and quoted with full reference of, and acknowledgement to the author(s) and the PJP. The contents are published with an international CC-BY-ND-4.0 License.