Renal Doppler ultrasound as predictor of renal impairment in patients with Hepatitis C and its correlation with serum creatinine

Abstract

Background: In patients with liver cirrhosis due to Hepatitis C virus, impaired renal haemodynamics leads to disturbance of glomerular filtration rate, real time estimation of renal haemodynamics can be assisted using renal Doppler. The aim of this study was to determine the correlation between renal resistive index (RI) and serum creatinine for evaluation of renal function in patients with Hepatitis C infection. Methods: This cross-sectional research was done from 22^nd November 2013 to 5^th November 2016 at Radiology Department, Mayo Hospital, Lahore. A total of 158 Hepatitis C positive patients divided to four groups (A, B, C, and D) according to disease stages and 79 healthy individuals were included as control group (group E). Serum creatinine was estimated and renal resistive index studied on colour Doppler, and correlation between serum creatinine and renal resistive index was studied. Results: Serum creatinine levels were considerably higher among diseased groups as compared to the control group. The highest creatinine level was observed in Group-D (1.05±0.20), followed by group C, B and A. Similarly, mean renal resistive index was significantly higher in diseased groups (highest: Group-D; 0.78 and 0.81 in right and left kidneys respectively). Conclusion: Renal resistive index has positive correlation with serum creatinine level. Resistive index taken on Doppler ultrasound can predict disease progression at an early stage, even before establishment of clinical symptoms and derangement of serum creatinine.

Pak J Physiol 2020;16(2):52?5