Morphologic patterns of endometrium in biopsy/curetting specimen of patients with abnormal uterine bleeding

Abstract

Background: Endometrial biopsy or curettage is the gold standard technique for evaluation of abnormal uterine bleeding (AUB) after ruling out the possibility of medical causes. The objective of our study is to determine the frequency of various endometrial pathologies in different age groups with complaints of AUB. Methods: This study was conducted in Pathology Department of DG Khan Medical College and Multan Institute of Kidney Diseases. It was a retrospective, descriptive cross-sectional study done over two years from 1 Jan 2017 to 31 Dec 2018. Sampling technique was convenience sampling. Endometrial biopsies and curetting were parts of this study. Histopathological findings of biopsy and curetting specimens were noted. Results: Total cases were 148 and data was categorized in reproductive (12–39 year), perimenopausal (40–50 year) and postmenopausal (above 50 year) age groups. In reproductive age group, secretory endometrium 22% was the most frequent finding followed by proliferative phase endometrium (20%). In perimenopausal age group, proliferative phase endometrium was the most common histological finding (31%). This was followed by secretory endometrium (23%) and chronic endometritis (17%). In postmenopausal age group, most common histological finding was exogenous hormone effect seen in 43% cases followed by non diagnostic tissue, atrophic endometrium and chronic endometritis, each 14.2%. Conclusion: We observed diverse findings like benign entities, infectious aetiology and malignancy as well.

Pak J Physiol 2020;16(1):24–7