Cardiac autonomic neuropathy in type 2 diabetes mellitus and control subjects

  • Shaheena Naz
  • Attiqa Khalid
  • Ijlal Zehra
  • Zuniarah Hamayun
  • Maria Gill
  • Hifza Noor Lodhi
Keywords: Visfatine, Diabetese, Coronary Artery Disease, Obesity, Waist circumference, Hip cirference, Body Mass Index

Abstract

Background: Mechanism of direct cardioprotective action of visfatin is still unclear. The aim of this study was to detect the serum visfatin concentration in healthy males and compare it with non-obese male patients of coronary artery disease to access the cardioprotective role of visfatin. Methodology: It was a cross-sectional, comparative study. Data was collected from July to December 2018 after obtaining informed consent of the subjects. The participants included 20 non-obese healthy males, and non-obese males angiographically confirmed having coronary artery disease. All participants were non-smoker, non-diabetic, and age matched from 35–55 years. Serum visfatin was analyzed using ELISA. Anthropometric measurements including waist circumference, hip circumference, and body mass index was evaluated and correlated with serum visfatin. Statistical analysis was done using SPSS-20. The values were considered significant at p<0.05. Results: Serum visfatin levels were significantly lower (3.90 ng/ml) in non-obese coronary artery disease group as compared to healthy males (4.85 ng/ml). No significant correlation was found with anthropometric measurements. Conclusion: Significant lower level of serum visfatin in non-obese male coronary artery disease patients depicts its probable cardioprotective role that is independent of anthropometric measurements.

Pak J Physiol 2021;17(1):30–2

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Published
2021-03-31
How to Cite
1.
Naz S, Khalid A, Zehra I, Hamayun Z, Gill M, Lodhi H. Cardiac autonomic neuropathy in type 2 diabetes mellitus and control subjects. PJP [Internet]. 31Mar.2021 [cited 27Jul.2021];17(1):30-2. Available from: https://pjp.pps.org.pk/index.php/PJP/article/view/1185