Anti-Müllarian Hormone levels in male patients suffering from depression

Abstract

Background: Anti-Müllerian Hormone (AMH) exerts a neuroprotective role by promoting neuroserpin expression through AMH dependent signalling pathway. The objective of this study was to determine the significance of serum Anti-Müllerian Hormone (AMH) levels in male patients suffering from depression. Methods: This case control study was carried out at the Department of Physiology and Multidisciplinary Research Laboratory, Islamic International Medical College, in collaboration with Armed Forces Institute of Mental Health, Military Hospital, Rawalpindi, from April 2016 to March 2018. A total of 96 males were divided into two groups. Group A (Control) consisted of 24 normal healthy males, and Group B (Cases) consisted of clinically diagnosed 72 male patients suffering from major depressive disorder. Serum AMH levels were evaluated in both the groups using ELISA method. Data was analysed using SPSS-22. Results: The serum AMH levels in Group B (8.54±0.62 ng/ml) were less than Group A (10.68±1.27), but the difference was not statistically significant. Conclusion: Patients suffering from depression have relatively low levels of serum AMH as compared to normal healthy adults but the difference is statistically not significant.

Pak J Physiol 2019;15(4):17?9