Effect of Almonds and cardioselective beta blocker on testicular weight in male Balb-C mice

  • Irum Rehman Margalla Institute of Health Scienes, Rawalpindi
  • Faizania Shabbir Physiology Department, Gujranwala Medical College, Gujranwala, Pakistan
  • Muhammad Imran Bajwa Department of Biochemistry, Islamic International Medical College, Rawalpindi, Pakistan
  • Riffat Shafi Shifa College of Medicine, Shifa Tameer-e-Millat University, Islamabad, Pakistan
  • Shakir Khan Biochemistry Department, Margalla Institute of Health Sciences, Rawalpindi, Pakistan
  • Naureen Waseem Department of Anatomy, Islam Medical College, Sialkot, Pakistan
Keywords: Almonds, Cardioselective, Beta Blocker, Testicular weight, Atenolol

Abstract

Background: Prunus amygdalis (almond) is focus of attention these days because of many benefits. It also acts as hypocholesterolemic agent so decreases hypertension risk factors. Complications of hypertension are increasing constantly. Beta blockers are frequently used antihypertensive agents. Atenolol (a β-blocker) also shows some side effects, it decreases testicular weight and almonds increase it. Study was designed to observe the effects of Prunus amygdalis and Atenolol on testicular weight to reveal that Prunus amygdalis can revert Atenolol’s effect or not. Methods: One hundred and twenty mice fulfilling inclusion criteria were divided into 4 equal groups. Group A served as control, group B was given Atenolol, group C was given almonds and group D was given both Atenolol and almonds. After 3 months, testes were dissected and weighed. Data was analyzed on SPSS-17, Mean±SD was calculated. One-way ANOVA was applied and p≤0.05 was considered significant. Results: The mean testicular weight in Group A was 0.127±0.01 gms, in Group B it was 0.113±0.01 gms, in Group C and Group D testicular weight was 0.136±0.01 gms and 0.120±0.01 gms respectively. When Group A was compared with Group B it was significantly reduced and no significant difference was found in Group C and Group D in comparison to Group A. Conclusion: Administration of Prunus amygdalis does not significantly affect testicular weight but Atenolol causes a significant decrease in it that can be reversed by Prunus amygdalis.

Pak J Physiol 2019;15(4):20−3

Author Biographies

Irum Rehman, Margalla Institute of Health Scienes, Rawalpindi

Assistant Professor, Physiology Department, Margalla Institute of Health Sciences, Rawalpindi, Pakistan.

Faizania Shabbir, Physiology Department, Gujranwala Medical College, Gujranwala, Pakistan

Associate Professor, Physiology Department, Gujranwala Medical College, Gujranwala, Pakistan

Muhammad Imran Bajwa, Department of Biochemistry, Islamic International Medical College, Rawalpindi, Pakistan

Senior Lecturer Biochemistry, Islamic International Medical College, Rawalpindi, Pakistan

Riffat Shafi, Shifa College of Medicine, Shifa Tameer-e-Millat University, Islamabad, Pakistan

Professor of Physiology, Shifa College of Medicine, Shifa Tameer-e-Millat University, Islamabad, Pakistan

Shakir Khan, Biochemistry Department, Margalla Institute of Health Sciences, Rawalpindi, Pakistan

Professor of Biochemistry, Margalla Institute of Health Sciences, Rawalpindi, Pakistan

Naureen Waseem, Department of Anatomy, Islam Medical College, Sialkot, Pakistan

Associate Professor of Anatomy, Islam Medical College, Sialkot, Pakistan

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Published
2019-10-29
How to Cite
1.
Rehman I, Shabbir F, Bajwa M, Shafi R, Khan S, Waseem N. Effect of Almonds and cardioselective beta blocker on testicular weight in male Balb-C mice. PJP [Internet]. 29Oct.2019 [cited 10Apr.2020];15(4):20-3. Available from: https://pjp.pps.org.pk/index.php/PJP/article/view/1151