Assessment of insulin like growth factor 1 and bone density in normal and β-thalassemia major children

  • Hira Sohail Department of Biochemistry, CMH Lahore Medical College and Institute of Dentistry, Lahore, Pakistan
  • Farhat Ijaz Department of Physiology, CMH Lahore Medical College and Institute of Dentistry, Lahore, Pakistan
  • Aaminah Malik Department of Biochemistry, CMH Lahore Medical College and Institute of Dentistry, Lahore, Pakistan
  • Rizwana Kamran Department of Medical Education, CMH Lahore Medical College and Institute of Dentistry, Lahore, Pakistan
  • Sahar Javed Department of Biochemistry, CMH Lahore Medical College and Institute of Dentistry, Lahore, Pakistan
  • Rana Khurram Aftab Department of Physiology, King Edward Medical University, Lahore, Pakistan
Keywords: Physiology, Insulin like Growth Factor, IGF, Bone Density

Abstract

Background: Hepcidin production is affected by multiple stimuli including iron status of the body, erythropoiesis, hypoxia and inflammatory conditions. This study was conducted to assess the effect of maternal hepcidin concentration on the different modes of delivery and maternal age groups. Cord blood hepcidin was also compared with neonatal gender. Methodology: The present study is observational type and conducted in Baqai Medical University from Sep 2015 to Mar 2016. To carry out the study, 25 healthy full-term pregnant females were included along with the cord blood samples. Five (5) ml blood was drawn from females and infants. Serum hepcidin were measured in both mothers and cord blood by using ELISA. Kruksal Wallace test was performed to observe the difference in hepcidin levels in females with different modes of delivery and with different age groups. Difference in neonatal hepcidin on the basis of gender was analyzed by Mann Whitney U test. Results: There was no significant difference between the maternal hepcidin values who delivered vaginally or underwent emergency or elective caesarean sections (p=0.871); however maternal age showed significant difference with maternal hepcidin (p=0.022). Neonatal hepcidin value did not vary on the basis of gender (p=0.475). Conclusion: Mode of delivery is independent of maternal and neonatal hepcidin levels. There were no differences gender-wise, whereas maternal age had effects on hepcidin levels of women.

Author Biographies

Hira Sohail, Department of Biochemistry, CMH Lahore Medical College and Institute of Dentistry, Lahore, Pakistan

+923454232459

Farhat Ijaz, Department of Physiology, CMH Lahore Medical College and Institute of Dentistry, Lahore, Pakistan

+923214932171

Rizwana Kamran, Department of Medical Education, CMH Lahore Medical College and Institute of Dentistry, Lahore, Pakistan

0300-9475222

Downloads

Download data is not yet available.
Published
2019-06-30
How to Cite
1.
Sohail H, Ijaz F, Malik A, Kamran R, Javed S, Aftab R. Assessment of insulin like growth factor 1 and bone density in normal and β-thalassemia major children. PJP [Internet]. 30Jun.2019 [cited 20Nov.2019];15(2):52-5. Available from: https://pjp.pps.org.pk/index.php/PJP/article/view/1091