Significance of lipid profile in antenatal patients for early diagnosis of preeclampsia

  • Fiza Ali Khan Department of obstetrics and Gynecology, Unit 2, Civil Hospital, Karachi
  • Tallat Naz Department of Physiology, Jinnah Sindh Medical University https://orcid.org/0000-0002-8693-9435
  • Arfa Azhar Department of Biological and Biomedical Sciences, Agha Khan University Hospital, Karachi.
  • Fatima Abid Department of Physiology, Jinnah Sindh Medical University, Karachi
  • Noorunnisa Memon Department of Physiology, Jinnah Sindh Medical University, Karachi.
  • Tariq Kamal Jafri Department of Physiology, Jinnah Sindh Medical University, Karachi
Keywords: Hypertriglyceridemia, Preeclampsia, Eclampsia, HELP syndrome, Intrauterine Growth Retardation, IGR

Abstract

Objective: To determine the importance of Lipid Profile in antenatal patients presenting with hypertriglyceridemia for early diagnosis of Preeclampsia at the time of delivery at tertiary care hospital located in Karachi.

Methodology: This cross-sectional research was done from 01- April 2013 to 01 October 2013 (6 months), at Department of Obstetrics & Gynecology, JPMC, Karachi. A total of 105 antenatal patients with age limit 18-40 years, single viable pregnancy with gestational age corresponding to>20 to 40thweek. Data was analyzed by SPSS version 16, Mean + SD, frequencies and percentages were calculated. Chi-square test was applied where necessary and P value less than 0.05 considered as significant.

Results:

 The mean age of the subjects was 29.67 ± 5.13 with parity 1.21 ± 0.67 and the gestational period 34.67 ± 3.53 weeks. The mean value of serum Triglyceride was 285 ± 40 mg/dL (201 -372 mg/dL). The frequency of preeclampsia in hypertriglyceridemia subjects was 14.29% (n=15). Eclampsia was identified in (13.33%, n=2), placental abruption occurred in (20%, n=3), HELLP syndrome was observed in (13.33%, n=2) and preterm deliveries happened in (26.67%, n=4) patients.

The age of mother, fetal age, parity as well as level of triglycerides in blood serum has influence on incidence of preeclampsia and its outcomes.

Conclusion: Our results signify the importance of fasting lipid profile in screening antenatal patients for early diagnosis and prevention of future complications in the mother as well as the child.

Author Biographies

Fiza Ali Khan, Department of obstetrics and Gynecology, Unit 2, Civil Hospital, Karachi

Senior registrar,

Department of obstetrics and Gynecology, Unit 2,

Dr..Ruth KM Pfau, Civil Hospital, Karachi

Tallat Naz, Department of Physiology, Jinnah Sindh Medical University

Instructor and Incharge,

Power Lab Teaching System, Department of Physiology,

Sindh Medical College,

Jinnah Sindh Medical University.

Arfa Azhar, Department of Biological and Biomedical Sciences, Agha Khan University Hospital, Karachi.

Clinical Instructor, Department of Biological and Biomedical Sciences,

Agha Khan University Hospital, Karachi.

Department of Biological and Biomedical Sciences,

Agha Khan University Hospital, Karachi.

 

Fatima Abid, Department of Physiology, Jinnah Sindh Medical University, Karachi

Assistant Professor,

Department of Physiology,

Sindh Medical College,

Jinnah Sindh Medical University, Karachi.

Noorunnisa Memon, Department of Physiology, Jinnah Sindh Medical University, Karachi.

Assistant Professor,

Department of Physiology,

Sindh Medical College,

 Jinnah Sindh Medical University, Karachi.

Tariq Kamal Jafri, Department of Physiology, Jinnah Sindh Medical University, Karachi

Associate Professor,

Department of Physiology, Sindh Medical College,

Jinnah Sindh Medical University, Karachi.

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Published
2020-02-04
How to Cite
1.
Khan F, Naz T, Azhar A, Abid F, Memon N, Jafri T. Significance of lipid profile in antenatal patients for early diagnosis of preeclampsia. PJP [Internet]. 4Feb.2020 [cited 10Apr.2020];15(4):24-6. Available from: https://pjp.pps.org.pk/index.php/PJP/article/view/1077