EFFECT OF ALLIUM SATIVUM ON EXPERIMENTALLY INDUCED HYPERLIPIDEMIA IN GUINEA PIGS
Background: Garlic (Allium sativum) is naturally occurring sulphur containing dietary agent belongs to family liliaceace. Members of this family like garlic and onions are found to have beneficial effect on atherosclerosis and ischemic heart diseases in experimental animals and humans. The objective of this study was to find out the effect of Allium sativum on experimentally induced hyperlipidemia in guinea pigs. Methods: Twenty-five guinea pigs were fed cholesterol (0.5 g/Kg body weight/day) for an initial period of 4 weeks. Cholesterol was then discontinued and the animals were divided into 3 groups. Group-I (control, n=7) was now fed normal diet with 1 ml normal saline. Group-II (n=9) was given 1 ml of aqueous extract with normal diet, and Group-III (n=9) was fed normal diet with 1 ml of alcoholic extract of garlic daily for 4 weeks. The garlic contents of both extracts were 2 g/ml. Fasting blood samples were collected at the end of 4 weeks after induced hyperlipidemia and finally at the end of the study (i.e., 8 weeks) for estimation of total serum cholesterol, serum triglyceride, HDLc, LDLc, VLDLc and atherogenic index was calculated in all 3 groups. Results: The aqueous and alcoholic extracts of garlic showed a significant hypolipidemic activity as they reduced significantly serum cholesterol, serum triglyceride, LDLc, VLDLc and atheriogenic index in hyperlipidemic guinea pigs (p<0.001) as compared to control group. The significant rise in HDLc was observed in group II but not in group I and III animals. On comparison between the two extracts, aqueous extract of garlic was found to be more potent hypolipidemic agent than to the alcoholic extract. Conclusion: Both extracts have hypolipidemic activity but aqueous extract of Allium sativum is more potent than alcoholic extract.
Pak J Physiol 2013;9(2):38â€“40
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