RELATIONSHIP OF OBESITY WITH INSULIN RESISTANCE IN POLYCYSTIC OVARIAN SYNDROME

Authors

  • Imrana Ihsan Qazi
  • Asma Tehreem Qazi
  • Farhat Ijaz
  • Samia Jawed
  • Rana Khurram Aftab Physiology department, KEMU
  • Shafia Rasool Qazi

Keywords:

Polycystic Ovary Syndrome, Insulin Resistance, Obesity, PCOS

Abstract

Background: Polycystic ovary syndrome (PCOS) is associated with insulin resistance, hyper-insulinemia and obesity. This study was designed to find out the levels of insulin resistance (IR) and its relationship with obesity in patients of PCOS. Methods: Seventy-four (74) females, diagnosed as PCO were selected from the Outpatient Department of Lady Atchison Hospital and divided in two groups. Group 1, PCOS with BMI <25 Kg/m2 and Group 2 with BMI ≥25 Kg/m2. Blood glucose and serum insulin were determined using ELISA. Insulin resistance was calculated using HOMA-IR method. Data was analyzed using SPSS-20. Mean±SD was used to present quantitative data. Normality of data was checked by one sample Kolmogorov Simonov test. Pearson’s correlation test was applied to see relationship between insulin resistance and obesity. The p≤0.05 was considered as significant. Results: Serum insulin in Group 2 (26.35±25.78) was statistically higher than Group 1 (16.63±13.58). Insulin resistance in Group 2 and Group 1 was 5.37±4.96 and 4.25±3.53 respectively, with no statistically significant difference (p=0.249). No significant correlation was found between IR and BMI in either cases or controls but overall a weak positive correlation was noted between the two variables. Conclusion: Insulin resistance and serum insulin were higher in females with polycystic ovarian syndrome. Insulin resistance and hyperinsulinaemia share the disease and might exacerbate the symptoms of disease. No significant correlation was found between insulin resistance and BMI

Downloads

Download data is not yet available.

References

1. Goodrazi MO, Azziz R. Diagnosis, epidemiology, and genetics of the polycystic ovary syndrome. Best Pract Res Clin Endocrinol Metab 2006;20:193–205.
2. Govind A, Obhrai MS, Clayton RN. Polycystic ovaries are inherited as an autosomal dominant trait: analysis of 29 polycystic ovary syndrome and 10 control families. J Clin Endocrinol Metab 1999;84(1):38–43.
3. Crosignani PG, Colombo M, Vegetti W, Somigliana E, Gessati A, Ragni G. Overweight and obese anovulatory patients with polycystic ovaries: parallel improvements in anthropometric indices, ovarian physiology and fertility rate induced by diet. Hum Reprod 2003;18:1928–32.
4. Dumesic DA, Oberfield SE, Stener-Victorin E, Marshall JC, Laven JS, Legro RS. Scientific Statement on the Diagnostic Criteria, Epidemiology, Pathophysiology, and Molecular Genetics of Polycystic Ovary Syndrome. Endocr Rev 2015;36:487–525.
5. Capllonch-Amer G, Lladó I, Proenza AM, García-Palmer FJ, Gianotti M. Opposite effects of 17-β estradiol and testosterone on mitochondrial biogenesis and adiponectin synthesis in white adipocytes. J Mol Endocrinol 2014;52(2):203–14
6. Haq F, Aftab O, Rizvi J. Clinical, biochemical and ultrasonographic features of infertile women with polycystic ovarian syndrome. J Coll Physicians Surg Pak 2007;17(2):76–80.
7. Hashemipour M, Fagihimani S, Zolfagahary B, Hovsepian S, Ahmadi F, Haghighi S. Prevalence of polycystic ovary syndrome in girls aged 14-18 years in Isfahan Iran. Horm Res 2004;62(6)278–82.
8. Corbould A, Zhao H, Mirzoeva S, Aird F, Dunaif A. Enhanced mitogenic signaling in skeletal muscle of women with polycystic ovary syndrome. Diabetes 2006;55:751–9.
9. Dewailly D, Gronier H, Poncelet E, Robin G, Leroy M, Pigny P, et al. Diagnosis of polycystic ovary syndrome (PCOS): revisiting the threshold values of follicle count on ultrasound and of the serum AMH level for the definition of polycystic ovaries. Hum Reprod 2011;26:3123–29.
10. Norman RJ1, Wu R, Stankiewicz MT. 4: Polycystic ovary syndrome. Med J Aust 2004;180(3):132–7.
11. Reaven GM. Insulin resistance: the link between obesity and cardiovascular disease. Med Clin North Am 2011;95(5):875–92.
12. Duleba AJ, Dokras A. Is PCOS an inflammatory process? Fertil Steril 2012;97(1):7–12.
13. Dunaif A, Fauser BC. Renaming PCOS-a two state solution. J Clin Endocrinol Metab 2013;98:4325–8.
14. Semple RK, Savage DB, Cochran EK, Gorden P, O'Rahilly S. Genetic Syndromes of Severe Insulin Resistance. Endocr Rev 2011;32:498–514.
15. Rojas J, Chávez M, Olivar L, Rojas M, Morillo J, Mejías J, et al. Polycystic Ovary Syndrome, Insulin Resistance, and Obesity: Navigating the Pathophysiologic Labyrinth. Int J Reprod Med 2014;2014:719050. doi: 10.1155/2014/719050.
16. González F, Rote NS, Minium J, Kirwan JP. In vitro evidence that hyperglycemia stimulates tumor necrosis factor-α release in obese women with polycystic ovary syndrome. J Endocrinol 2006;188(3):521–9.
17. Samy N, Hashim M, Syed M, Said M. Clinical significance of inflammatory markers in PCOS; Their relationship to insulin resistance and body mass index. Dis Markers 2009;26:163–70.
18. WHO. Asia-Pacific Steering Committee. The Asia-Pacific Perspective: Redefining obesity and its treatment; International Diabetes Institute.Health Communications Australia; St Leonards, Australia: 2000.p. 19.
19. Jalilian A, Kiani F, Sayehmiri F, Sayehmiri K, Khodaee Z, Akbari M. Prevalence of polycystic ovary syndrome and its associated complications in Iranian women: A meta-analysis. Iran J Reprod Med 2015;13:591–604.
20. Al-Watify DGO. Abnormalities of hormones and inflammatory cytokines in women affected with polycystic ovary syndrome. J Nat Sci Res 2014;4(6):49–53.
21. Maryam KK, Arian-pour N, Safari A, Roozegar R. Body mass index (BMI) related insulin resistance in polycystic ovarian syndromeamong patients referred to gynecology clinic of Imam Reza Hospital, Tehran, Iran. J Clin Med Res 2012;4(7):84–8.
22. Zawadski JK, Dunaif A. Diagnostic criteria for polycystic ovary syndrome: Towards a rational approach. In: Dunaif A, Givens JR, Haseltine F, (Eds). Polycystic Ovary Syndrome. Bostan: Blackwell Scientific;1992.p. 377–84.
23. Areej H, Catherine MG. Polycystic ovary syndrome in adolescence. Postgrad Obstet Gynecol 2008;28(5):1–8.
24. Katsikis I, Karkanaki A, Misichronis G, Delkos D, Kandaraki EA, Panidis D. Phenotypic expression, body mass index and insulin resistance in relation to LH levels in women with polycystic ovary syndrome. Eur J Obstet Gynecol Reprod Biol 2011;156(2):181–5.
25. Reyes-Muñoz E, Ortega-González C, Martínez-Cruz N, Arce-Sánchez L, Estrada-Gutierrez G, Moran C, et al. Association of obesity and overweight with the prevalence of insulin resistance, pre-diabetes and clinical-biochemical characteristics among infertile Mexican women with polycystic ovary syndrome: a cross-sectional study. BMJ Open 2016;6(7):e012107.
26. De Leo V, Musacchio MC, Cappelli V, Massaro MG, Morgante G, Petraglia F. Genetic, hormonal and metabolic aspects of PCOS: an update. Reprod Biol Endocrinol 2016;14(1):38.
27. Dasgupta A, Khan A, Banerjee U, Ghosh M, Pal M, Chowdhury KM, et al. Predictors of insulin resistance and metabolic complications in polycystic ovarian syndrome in an Eastern Indian Population. Indian J Clin Biochem 2013;28(2):169–76.
28. Cupisti S, Kajaia N, Dittrich R, Duezenli H, W Beckmann M, Mueller A. Body mass index and ovarian functions are associated with endocrine and metabolic abnormalities in women with hyperandrogenic syndrome. Eur J Endocrinol 2008;158:711–9.
Pak J Physiol 2018;14(3)

Downloads

Published

20-08-2018

How to Cite

1.
Qazi II, Qazi AT, Ijaz F, Jawed S, Aftab RK, Qazi SR. RELATIONSHIP OF OBESITY WITH INSULIN RESISTANCE IN POLYCYSTIC OVARIAN SYNDROME. Pak J Phsyiol [Internet]. 2018 Aug. 20 [cited 2024 Apr. 20];14(3):46-9. Available from: https://pjp.pps.org.pk/index.php/PJP/article/view/196

Issue

Vol. 14 No. 3 (2018): Pakistan Journal of Physiology

Section

Original Article

License

Pakistan Journal of Physiology, Pak J Physiol, PJP is FREE for research and academic purposes. It can be freely downloaded and stored, printed, presented, cited and quoted with full reference of, and acknowledgement to the PJP.