Association of serum resistin with lipids in hypertensives and coronary artery disease patients

  • Sobia Niaz Assistant Prof of Physiology, FMH College of Medicine & Dentistry, LHR
  • Javaria Latif Assistant Professor Physiology department, Shahida Islam Medical & Dental Complex, Lodhran
  • Farhat Ijaz Assistant Prof of Physiology, CMH LMC, LHR
  • Saima Mukhtar Assistant Prof of Physiology, Rehbar Medical & Dental College, LHR
  • Kanwal Ijaz Fatima Memorial Hospital College of Medicine & Dentistry, Lahore
  • Nida Ali Assistant Prof of Physiology, FMH College of Medicine & Dentistry, LHR
  • Rana Khurram Aftab Physiology department, KEMU
Keywords: Resistin, Hypertension, HTN, Coronary artery disease, Lipid profile, Decrease

Abstract

Background: Resistin, an adipocytokine was initially discovered in rodents as a regulator of lipidogenesis but now different clinical researches have proved its controversial role in inflammation also. Resistin is found to be involved in processes leading to atherosclerotic changes and ultimately to hypertension (HTN) and coronary artery disease. The present study was designed to observe the association of serum resistin with lipid levels in patients of hypertension and coronary artery disease. Methodology: Eighty participants in four groups of equal number were selected including normal blood pressure, newly diagnosed cases of hypertension, hypertensive patients having myocardial infarction and angina pectoris respectively. After consent, history taking and general physical examination of the subjects (to rule out any ongoing disease process), their fasting blood samples were collected. Serum resistin was determined by using standard technique of enzyme linked immunosorbent assay, while lipid parameters were estimated by kits based on enzymatic methods. Results: The collected data were analyzed using SPSS-17. The values (mean±SD) of serum resistin, triglycerides and low-density lipoproteins were found progressively and significantly increased while serum high-density lipoproteins were significantly decreased in study groups with increased severity of disease. Conclusions: Serum levels of resistin, triglycerides and LDL are significantly raised while serum HDL levels are significantly lowered in patients of hypertension and coronary artery disease.

Pak J Physiol 2019;15(3):6−9

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Published
2019-08-02
How to Cite
1.
Niaz S, Latif J, Ijaz F, Mukhtar S, Ijaz K, Ali N, Aftab R. Association of serum resistin with lipids in hypertensives and coronary artery disease patients. PJP [Internet]. 2Aug.2019 [cited 23Jan.2020];15(3):6-. Available from: http://pjp.pps.org.pk/index.php/PJP/article/view/1085

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