TY - JOUR AU - Ashfaq, Mehvish AU - Jabeen, Sidra AU - Mubarak, Sadia AU - Rasul, Amina AU - Hamid, Sidra AU - Javed, Ambreen PY - 2023/03/31 Y2 - 2024/03/28 TI - PROPERTIES OF FATIGUE BETWEEN SLOW AND FAST MUSCLES OF MALE AND FEMALE DIABETIC RATS JF - Pakistan Journal of Physiology JA - Pak J Phsyiol VL - 19 IS - 1 SE - Original Article DO - UR - https://pjp.pps.org.pk/index.php/PJP/article/view/1514 SP - 7-10 AB - <p><strong>Background: </strong>The metabolic disorder of Type 2 Diabetes Mellitus (T2DM) has deleterious effects on skeletal muscle contractile functions. This study aimed to compare parameters of fatigue between slow and fast skeletal muscles of male and female type 2 diabetic Sprague-Dawley rats. <strong>Methodology: </strong>This was a quasi experimental study conducted at Army Medical College Rawalpindi and National Institute of Health, Islamabad. Forty Sprague Dawley rats in good health were split into groups I (Control) and II (Diabetics) of 20 rats each. Each group had 10 male and 10 female rats. Diabetic groups were given intra-peritoneal streptozotocin (STZ), 35 mg/Kg body weight on 15<sup>th</sup> day. Control groups were fed a normal diet and diabetic rats were given diet with high fat. On 21<sup>st</sup> day body weight, blood glucose and triglyceride/high density lipoprotein ratio were estimated to confirm extraction of type 2 diabetes mellitus. Intact Soleus and Extensor Digitorium Longus muscles were removed and fixed in organ bath system having Krebs-Ringer buffer solution and connected to data acquisition unit (iWorx<sup>®</sup>) to study their fatigability parameters. Independent samples <em>t</em>-test was used for statistical analysis. <strong>Results: </strong>Slow and fast skeletal muscles in diabetic rats showed reduction in resistance to and recovery from fatigue. Fatigue parameters between male and female diabetic rats revealed no significant differences. <strong>Conclusion:</strong> Fatigue parameters do not differ between male and female diabetic rats.</p><p><strong>Pak J Physiol 2023;</strong>19(1):7?10</p> ER -