@article{Ijaz_Aftab_Zubair_Aftab_2018, title={CORRELATION OF TUMOUR NECROSIS FACTOR-α WITH OBESITY INDUCED INSULIN RESISTANCE IN TYPE 2 DIABETES MELLITUS}, volume={14}, url={https://pjp.pps.org.pk/index.php/PJP/article/view/228}, abstractNote={<p><strong>Background:</strong> Obesity is a major cause of many metabolic disorders characterized by chronic inflammation that is linked with T2DM and insulin resistance. Tumour Necrosis Factor Alpha (TNF-α) is remarkably higher in obese people. The aim of this study was to determine the levels of TNF-α and its correlation with insulin resistance and body mass index in type 2 diabetic patients. <strong>Methods:</strong> This study was conducted at Diabetic Clinic of Mayo Hospital, Lahore. TNF-α levels were determined and correlated with insulin resistance and body mass index in 90 obese type 2 diabetics. TNF-α and serum insulin were determined using ELISA. Insulin resistance was calculated by HOMA-IR. Pearson correlation test was used to correlate TNF-α with Insulin Resistance and body mass index, and <em>p</em>≤0.05 was considered statistically significant. <strong>Results:</strong> There was a strong positive correlation of fasting insulin and HOMA-IR with TNF-α (<em>r</em>=0.986, <em>p</em><0.001). There was also strong positive correlation of TNF-α with BMI.<strong> Conclusion:</strong> Increased inflammation in obese diabetics explains the role of TNF-α in insulin resistance caused by obesity. Weight reduction in obese individuals will help in reducing TNF-α levels and to improve insulin sensitivity in T2DM.</p> <p><strong>Pak J Physiol 2018;</strong>14(2):18–20</p>}, number={2}, journal={Pakistan Journal of Physiology}, author={Ijaz, Farhat and Aftab, Rana Khurram and Zubair, Syed M. and Aftab, Rana Rakhshan}, year={2018}, month={Jun.}, pages={18–20} }