@article{Ashraf_Imran_Naeem_Khan_2022, title={COMPARISON OF T WAVE ALTERNANS IN PATIENTS WITH ISCHEMIC AND NON-ISCHEMIC CARDIOMYOPATHY}, volume={18}, url={https://pjp.pps.org.pk/index.php/PJP/article/view/1246}, abstractNote={<p><strong>Background: </strong>Early detection of T-wave alternans in patients with cardiomyopathy can help in risk stratification of ventricular arrhythmias leading to sudden cardiac death. The present study was designed to compare T-wave alternans in patients with ischemic and non-ischemic cardiomyopathy. <strong>Methods:</strong> This cross-sectional comparative study was carried out at Department of Cardiac Electrophysiology, Armed Forces Institute of Cardiology, Rawalpindi during 2019. Thirty patients with ischemic cardiomyopathy along with equal number of non-ischemic cardiomyopathy of matched age and gender were recruited through non-probability purposive sampling. Patients with diabetes mellitus, cerebrovascular accident, heart failure, bundle branch block, systemic arterial hypertension and ongoing anti-arrhythmic therapy were excluded from the study. DMS 300-4L Holters were used to obtain ambulatory ECG recordings. Cardio Scan Premier 12 Lux software was used for analysis of T-wave alternans. <strong>Results:</strong> A total of 60 subjects were studied. The mean value of T-wave alternans was 52.73±30.76 µV and 57.47±36.54 µV for patients with ischemic and non-ischemic cardiomyopathy respectively. The difference between mean values was statistically insignificant (<em>p</em>=0.59). T-wave alternans was present in 8 (26.7%) patients with ischemic cardiomyopathy, while 5 (16.7%) patients with non-ischemic cardiomyopathy showed positive T-wave alternans and the difference was statistically insignificant (<em>p</em>=0.35). <strong>Conclusion: </strong>The mean value of T-wave alternans and frequency of patients with positive T-wave alternans is not significantly different in ischemic and non-ischemic cardiomyopathy.</p> <p><strong>Pak J Physiol 2022;</strong>18(1):9?12</p>}, number={1}, journal={Pakistan Journal of Physiology}, author={Ashraf, Hira and Imran, Madiha and Naeem, Sara and Khan, Muhammad Alamgir}, year={2022}, month={Mar.}, pages={9–12} }