TY - JOUR AU - Taimoor, Alruba AU - Nazir, Aamir AU - Raza, Nuzhat AU - Qureshi, Sadaf Anwar AU - Ayub, Muhammad AU - Shirwany, Tanvir Ali Khan PY - 2017/06/30 Y2 - 2024/03/28 TI - LIVER FUNCTION TESTS IN SECOND AND THIRD TRIMESTER PRIMIGRAVIDA IN NORMAL PREGNANCY AND PREECLAMPSIA JF - Pakistan Journal of Physiology JA - Pak J Phsyiol VL - 13 IS - 2 SE - Original Article DO - UR - https://pjp.pps.org.pk/index.php/PJP/article/view/47 SP - 25-28 AB - <p><strong>Background: </strong>Preeclampsia is a common obstetrical problem affecting 5–10% of pregnant females. The objective of this study was to determine and compare liver function tests in primigravidas in second and third trimesters of normal pregnancy and preeclampsia. <strong>Methods:</strong> A cross-sectional comparative study was conducted that included 100 subjects aged 15–40 years with normal pregnancy, and preeclamptic primigravidas of second and third trimester. Their liver function tests were carried out and compared among the study groups. <strong>Results:</strong> The mean age of the subjects was 25.92±5.56 years, mean systolic BP was 136.3±24.623 mmHg, mean diastolic blood pressure was 87.8±15.736 mmHg.&nbsp;&nbsp; There were statistically significant differences in AST, ALT, ALP, and serum albumin among cases and controls of both 2<sup>nd</sup> and 3<sup>rd </sup>trimester (<em>p</em>&lt;0.05). However, serum total bilirubin among preeclamptics of 2<sup>nd</sup> and 3<sup>rd</sup> trimesters, and also between controls and preeclamptics of 3<sup>rd</sup> trimester was significantly increased (<em>p</em>&lt;0.05). Serum AST and ALT were significantly decreased among controls of 3<sup>rd</sup> trimesters compared to 2<sup>nd</sup> trimester while ALP was significantly increased in 3<sup>rd</sup> trimester controls compared to 2<sup>nd</sup> trimester controls. Serum albumin was significantly decreased in both 2<sup>nd</sup> and 3<sup>rd</sup> trimester preeclamptics compared to controls. <strong>Conclusion:</strong> Serum AST, ALP, and bilirubin was significantly increased in 3<sup>rd</sup> trimester preeclamptics compared to 2<sup>nd</sup> trimester preeclamptics.</p><p><strong>Keywords:</strong> Preeclampsia, liver function tests, primarygravidas</p><p><strong>Pak J Physiol 2017;</strong>13(2):25–8</p> ER -