TY - JOUR AU - Nawaz, Usman AU - Noor, Mudassar AU - Fazal, Imran AU - Waheed, Akbar AU - Khan, Saleem Ahmad PY - 2019/03/31 Y2 - 2024/03/28 TI - CLOPIDOGREL RESISTANCE AND ITS RELATION WITH AGE AND GENDER JF - Pakistan Journal of Physiology JA - Pak J Phsyiol VL - 15 IS - 1 SE - Original Article DO - UR - https://pjp.pps.org.pk/index.php/PJP/article/view/1006 SP - 25-28 AB - <p><strong>Introduction/Objective: </strong>&nbsp;Clopidogrel is an antiplatelet drug used for ischemic heart disease patients, but it is not equally effective in all the patients due to clopidogrel resistance. Clopidogrel resistance is a precursor to secondary adverse cardiac events. This study was conducted to assess the magnitude of clopidogrel resistance in Pakistan and to find its association with age and gender<strong>.&nbsp;</strong><strong>Methodology:</strong> This was a cross sectional study conducted from 2015-2017 at Army Medical College, National University of Medical Sciences, Rawalpindi, Pakistan. We included 390 ischemic heart disease patients, who were taking clopidogrel 75 mg/day for at least 7 days. Blood samples of all these patients were taken and platelet aggregation studies were performed with the help of light transmission aggregometer using adenosine diphosphate as an agonist.&nbsp;<strong>Results: </strong>Our study demonstrates that 75.1% of the patients were clopidogrel responders while 24.9% patients were clopidogrel resistant. Mean platelet aggregation of clopidogrel resistant patients was significantly higher than clopidogrel responders (60.22 ± 7.33% vs 27.73 ± 12.17%), p&lt;0.001. There was no effect of age and gender on clopidogrel response status with p=0.266 and p=0.860 respectively. There was no difference in mean platelet aggregation of both genders (p=0.532) and among different age groups (p=0.234).&nbsp;<strong>Conclusion: </strong>Clopidogrel resistance is quite common in Pakistan affecting as much as quarter of local population and it is not specific to any age group or gender.&nbsp;</p><p><strong>Pak J Physiol 2019;</strong>15(1):25-8</p> ER -