@article{Saad_Masood_Khan_Taj_Raza_Malik_2020, title={Frequency of acquired anti-thrombin III deficiency in patients with disseminated intravascular coagulation}, volume={15}, url={https://pjp.pps.org.pk/index.php/PJP/article/view/1178}, abstractNote={<p><strong>Background:</strong> Anti-thrombin III (AT III) is a glycoprotein consists of 432 amino acids which inactivates several enzymes of coagulation system. Acquired AT III deficiency is observed in a condition when activation of coagulation system is inappropriate like Disseminated Intravascular Coagulation (DIC). This study was conducted to determine the frequency of anti-thrombin III deficiency in patients with DIC. <strong>Methods:</strong> This cross-sectional descriptive study was conducted in Hayatabad Medical Complex Peshawar from October 2014 to April 2017. A total of 136 patients were included in the study. Consecutive, non-probability sampling was performed. Diagnosed patients of disseminated intravascular coagulation (DIC) of both genders aged 18–60 years with D-dimer >1,000 ng/dl were included. Patients with coagulation abnormalities other than DIC were excluded. Chromogenic determination of AT III was done. <strong>Results:</strong> Mean age of the patients was 45±10.8 years, males were 60%, and females were 40%. D-dimer level range was 1,000–2,000 ng/dl in 59% cases and >2,000 ng/dl in 41% cases. Mean D-dimer levels was 2,000±2071 ng/dl. Anti-thrombin deficiency was present in 22.79% patients. <strong>Conclusion:</strong> The frequency of acquired anti-thrombin deficiency was found to be 23% in patients with disseminated intravascular coagulation.</p> <p><strong>Pak J Physiol 2019;</strong>15(4):35-7</p>}, number={4}, journal={Pakistan Journal of Physiology}, author={Saad, Ammar Bin and Masood, Shahtaj and Khan, Javed Iqbal and Taj, Sadia and Raza, Ali and Malik, Sohail Ahmed}, year={2020}, month={Jan.}, pages={35–37} }