EFFECT OF THIAZOLIDINEDIONES ON ADIPOCYTOKINES AND LIPID PROFILE IN INSULIN RESISTANT SPRAGUE DAWLEY RATS

  • Iftekhar Yousaf Department of Physiology, Army Medical College, National University of Medical Sciences, Rawalpindi
  • Kamil Asghar Imam Department of Physiology, Army Medical College, National University of Medical Sciences, Rawalpindi, Pakistan.
  • Sobia Waqas Islamic International Medical College, Rawalpindi, Pakistan

Abstract

Background: Insulin resistance is manifested by decreased effect of fixed quantity of insulin on glucose metabolism leading to type 2 diabetes mellitus. Visceral obesity has been positively correlated with insulin resistance but its mechanism is not fully defined. Insulin resistance may be the consequence of adipocytokines including visfatin and resistin. This study was designed to observe the effects of thiazolidinediones on lipid profile and levels of adipocytokines (visfatin and resistin) in insulin resistant Sprague Dawley rats. Methods: Ninety Sprague Dawley rats were randomly divided into three groups. Group I served as control. Rats in Group II and III were made insulin resistant diabetics. Group III was treated with rosiglitazone after development of diabetes. Plasma glucose, serum triglycerides (TG), HDL, TG: HDL ratio and serum adipocytokines (visfatin, resistin) levels were analyzed. Results: Body weight and plasma glucose were significantly increased (p<0.05) along with TG: HDL ratio (p<0.05) in group II and group III at the end of 4th week. Serum visfatin and resistin levels also increased significantly (p<0.05) in group II and III at the end of 4th week. Treatment of group III with rosiglitazone led to improvement in insulin resistance with decrease in serum resistin levels (p<0.05) and increase in serum visfatin levels (p<0.05). Rosiglitazone treatment decreased serum TG level and increased serum HDL level. Conclusions: Deranged lipid profile and increased serum resistin levels indicate insulin resistance and impending hyperglycaemia. Thiazolidinediones augment sensitivity of insulin to restore normoglycemia by improving lipid profile, decreasing serum resistin levels and improving serum visfatin levels.


Pak J Physiol 2017;13(4):3–6

Author Biographies

Iftekhar Yousaf, Department of Physiology, Army Medical College, National University of Medical Sciences, Rawalpindi

Department of Physiology,

Army Medical College,

National University of Medical Sciences,

Rawalpindi.

Kamil Asghar Imam, Department of Physiology, Army Medical College, National University of Medical Sciences, Rawalpindi, Pakistan.

Maj. Dr. Kamil Asghar Imam,

Department of Physiology,

Army Medical College,

National University of Medical Sciences,

Rawalpindi, Pakistan. Cell: +92-340-8009304

Email: kamzimam@gmail.com

Sobia Waqas, Islamic International Medical College, Rawalpindi, Pakistan

Department of Physiology,

Islamic International Medical College,

Rawalpindi, Pakistan.

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Published
2017-12-31
How to Cite
YOUSAF, Iftekhar; IMAM, Kamil Asghar; WAQAS, Sobia. EFFECT OF THIAZOLIDINEDIONES ON ADIPOCYTOKINES AND LIPID PROFILE IN INSULIN RESISTANT SPRAGUE DAWLEY RATS. Pakistan Journal of Physiology, [S.l.], v. 13, n. 4, p. 3-6, dec. 2017. ISSN 2073-1183. Available at: <http://pjp.pps.org.pk/index.php/PJP/article/view/77>. Date accessed: 17 feb. 2018.

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