EFFECT OF IRON WITH MINERAL AND MULTIVITAMIN SUPPLEMENTATION ON TRANSFERRIN SATURATION INDEX IN IRON DEFICIENCY ANEMIA DURING PREGNANCY

  • Samina Malik Associate Professor, Department of Physiology, Avicenna Medical College, Lahore, Pakistan
  • Aalia Dilawar Department of Pathology
  • Ghazala Qureshi Physiology, Akhtar Saeed Medical & Dental College, Lahore
  • Usman Khurram FMH College of Medicine & Dentistry, †CMH Lahore Medical & Dental College, Lahore
  • Ramsha Khan CMH Lahore Medical & Dental College, Lahore
  • Samina Malik Avicenna Medical College, Lahore
Keywords: Iron deficiency anaemia, iron supplement, multiple micronutrients, Pregnancy

Abstract

Background: Anaemia during pregnancy is associated with labour/delivery complications like, preterm delivery, low birth weight, reduced infant iron stores, impaired mother-child interactions, and increased infant and maternal mortality. The objective of current study was to find out whether supplementation of oral iron (three times a day) would affect Transferrin Saturation Index as effectively as supplementation with combination therapy (iron with multiple vitamin and minerals) in pregnant women with iron deficiency anaemia. Methods: Two hundred primigravidae visiting the obstetric outpatient department of Services Hospital Lahore, between 14th and 18th week of gestation were included in the study. Among 200 pregnant women, 100 women receiving once daily tablet of supplementation including 2 supplements in tablet form containing 60 mg Iron with multivitamin and minerals were considered as group A. Group B consisted of 100 women receiving ferrous sulfate tablet three times a day (60 mg elemental iron). Level of serum iron and Total Iron Binding Capacity (TIBC) were estimated by standard kit methods. After informed consent, blood samples were taken between 14th to 18th week of gestation and follow-up samples were taken at 36th week of gestation. Results: Levels of hematological parameters were compared before and after therapy at 14th to 18th week and 36th weeks respectively.  The level of TIBC was increased significantly (p<0.001) after the combination therapy. Ratio of iron to TIBC or transferrin saturation index was markedly decreased after the combination therapy in this group. The level of TIBC was significantly decreased (p<0.001) after the therapy. Ratio of iron to TIBC or transferrin saturation index was markedly increased after the iron therapy in this group. 

Conclusion: Supplementation of iron with multivitamins and minerals has a role in increasing TIBC in pregnant females with iron deficiency anaemia.

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Published
2018-05-28
How to Cite
1.
Malik S, Dilawar A, Qureshi G, Khurram U, Khan R, Malik S. EFFECT OF IRON WITH MINERAL AND MULTIVITAMIN SUPPLEMENTATION ON TRANSFERRIN SATURATION INDEX IN IRON DEFICIENCY ANEMIA DURING PREGNANCY. PJP [Internet]. 28May2018 [cited 27Feb.2021];8(1):19-2. Available from: http://pjp.pps.org.pk/index.php/PJP/article/view/753