INFLUENCE OF SERUM HOMOCYSTEINE ON PLATELET COUNT IN STABLE HEMODIALYSIS PATIENTS

Authors

  • Hamid Nasri Internist, Nephrologist,Associate Professor, Shahrekord University of Medical Sciences, Hajar Medical, Educational and Therapeutic Center, Department of Internal Medicine, Shahrekord, Iran

Keywords:

Platelet count, hemodialysis, end-stage renal failure, serum homocysteine

Abstract

Background: The objective of this study was to elucidate whether and how the level of homocysteine as a cause of hemostatic abnormalities affects platelet count in hemodialysis patients with uremia. Methods: A cross-sectional study was conducted on patients with end-stage renal disease (ESRD) who were undergoing maintenance hemodialysis treatment with acetate basis dialysate and polysulfone membranes. Serum total homocysteine (HCY), hemoglobin, platelet (PLT), and white blood cell (WBC) counts were measured. Levels of serum calcium (Ca), phosphorus (P), and magnesium (Mg) were also measured. There were 39 study patients (15 female, 24 male) with a mean age of 46 ± 18 years.Results: The duration of dialysis treatment was 31± 35 months (median, 18 months). The value of serum homocysteine for all the patients was 5 ± 2.5 μmol/L (median, 4.5 μmol/L). The mean PLT count was 155 ±77 x 10³ u/L (median, 158 x 10³ u/L). Conclusion: This study showed a significant positive correlation of PLT count with serum homocysteine (r=0.35, P=0.044). In hemodialysis patients high homocystiene levels make the platetes more likely to clump and cause clots and contribute to the possibility of thrombotic events among these patients .

Downloads

Download data is not yet available.

Downloads

Published

31-12-2006

How to Cite

1.
Nasri H. INFLUENCE OF SERUM HOMOCYSTEINE ON PLATELET COUNT IN STABLE HEMODIALYSIS PATIENTS. Pak J Phsyiol [Internet]. 2006 Dec. 31 [cited 2024 Mar. 28];2(2):4-7. Available from: https://pjp.pps.org.pk/index.php/PJP/article/view/674