EFFECT OF SNAKE VENOM ON NUCLEIC ACIDS AND TOTAL PROTEINS IN VARIOUS NORMAL AND CANCEROUS ANIMAL TISSUES

Authors

  • Din Muhammad Shaikh Department of Physiology Isra University. Sindh
  • Rukhsana Jokhio Sindh University, Hyderabad

Keywords:

Snake venom, Nucleic Acid, Tissue, Total Proteins

Abstract

Venoms have occasional medical uses. This study was carried out to determine effect of cobra snake venom on nucleic acid and total proteins in various normal and cancerous animal tissues. Methods: In this vitro study the venom with varying concentrations was incubated with homogenates of liver, heart and kidney of normal tissues. Reduction in RNA / DNA levels was observed. Results: Our results indicate that nucleic acids are more sensitive. However the effect of snake venom on normal skin tissue was insignificant when compared with cancerous tissue. The dose response curve shows that the lowest concentration of venom at 25 μg / ml (a survival dose) produced maximum inhibition of both nucleic acids. The opposite and linear response was observed in protein contents. Conclusion: It can be assumed from the present study that the venom might have therapeutic effect at a dose of 25 μg /ml in cancerous tissues.

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Published

31-03-2005

How to Cite

1.
Shaikh DM, Jokhio R. EFFECT OF SNAKE VENOM ON NUCLEIC ACIDS AND TOTAL PROTEINS IN VARIOUS NORMAL AND CANCEROUS ANIMAL TISSUES. Pak J Phsyiol [Internet]. 2005 Mar. 31 [cited 2024 Apr. 20];1(1-2). Available from: https://pjp.pps.org.pk/index.php/PJP/article/view/594

Issue

Vol. 1 No. 1-2 (2005): Pakistan Journal of Physiology

Section

Original Article

License

Pakistan Journal of Physiology, Pak J Physiol, PJP is FREE for research and academic purposes. It can be freely downloaded and stored, printed, presented, cited and quoted with full reference of, and acknowledgement to the PJP.