• Muhammad Tariq Department of Physiology, Kabir Medical College
  • Riffat Sultana Department of Physiology, Khyber Girls Medical College
  • Amin Ul Haq Department of Biochemistry, Khyber Girls Medical College, Peshawar, Pakistan
Keywords: Erythrocytes, Heroin addiction, Smoking


Background: The harmful components of tobacco smoke nicotine, tar and carbon monoxide affect different haematological parameters. Heroin affects almost every system of the body including blood and its components. The objective of the present study was to compare the effects of cigarette smoking and heroin abuse on haematological parameters especially erythrocyte indices. Method: The present study was conducted in Physiology department; Khyber Medical College Peshawar from Jan 2006 to Dec 2007. One hundred age and sex matched subjects were included in the study. The subjects were divided into three groups, i.e., 40 cigarette smokers and 40 heroin addicts, with 20 controls. Data were statistically analysed using SPSS-10. Results: The mean haemoglobin value of cigarette smokers was significantly higher as compared to control subjects (p<0.001). The mean haemoglobin value of heroin addicts was significantly lower when compared with either control group or cigarette smokers (p<0.001). Conclusion: Haematological parameters vary with smoking and heroin abuse. There should be no illusions as to the dangers of cigarettes. The combination of a highly addictive, pharmacologically active substance–nicotine–and an array of noxious chemicals cunningly packaged in highly efficient delivery mechanism can drastically affect health.

Pak J Physiol 2013;9(2):32–4


1. Gilman SL, Xun Z. Introduction. In: Gilman SL, Xun Z (eds). Smoke: a global history of smoking. London: Reaktion Books; 2004.
2. Ahmed Z, Habib U, Kafeel M, Khan MH. Blood parameters and smoking pattern in Peshawar Colleges. Pak J Med Res 1995:34(3):190–3.
3. Robicsek F. Ritual smoking in Central America. In: Gilman SL, Xun Z (eds). Smoke: a global history of smoking. London: Reaktion Books; 2004.
4. Pakistan Health Education Survey 1991-1992. Islamabad: Ministry of Health, Government of Pakistan; 1993.pp.115–22.
5. Alam SE. Prevalence and pattern of smoking in Pakistan. J Pak Med Assoc 1998;48:64–6.
6. Jafarey NA. Tobacco (editorial) J Pak Med Assoc 1998;48(3):61.
7. Collin J, Gilmore A. Developing countries. In: Goodman J (ed), Tobacco in history and culture: an encyclopedia. Farmington Hills MI: Charles Scribner’s Sons; 2004.
8. WHO. Chief Data Centre of WHO Monica Project. National Public Health Institute. Department of Epidemiology. Manver heimintie 166, SF-00280. Helsinki, Finland:1983.
9. Lopez AD, Collishaw NE, Piha T. A descriptive model of the cigarette epidemic in developed countries. Tob Control 1994;3:242–7.
10. Doll R, Petro R. Causes of cancer. Oxford: Oxford University Press; 1988.
11. Ilyas M, Naeem AJ. Tobacco and Health. In: Ilyas M (Ed). Community Medicine and public Health. 6th ed. Karachi: Time Publishers; 2013.pp. 1023–32.
12. Bridges RB, Wyatt RJ, Rehm SR. Effect of smoking on peripheral blood leukocytes and serum anti-proteases. Eur J Respir Dis Suppl 1985;139:24–33.
13. World Health Organization. World health report 2002: reducing risk, promoting healthy life. Geneva: WHO; 2002.
14. World Health Organization. Report on the Global Tobacco Epidemic. 2009.
15. World Health Organization. Report on the Global Tobacco Epidemic, 2008.
16. Noble RC, Penny BB. Comparison of leucocytes count and function in smoking anon smoking young men. Infect Immun 1975;12(3):550–5.
17. Rosello J, Olona M, Oltra C, Campins M, Vague J, Carrera A. Effects of smoking on hematological parameters in healthy people. Med Clin (Bare) 1990;94(10):368–71.
18. World Health Organization. Global Status Report–Paistan-1997: Tobacco Information and Prevention Source (TIPS), Centers for Disease Control. Available from: who/pakistan . [Accessed February 28, 2006.]
19. Global Effects of Tobacco Use. Available from: [Accessed February 28, 2006].
20. Zeb J, Tayyab M, Khan H, Qureshi SA, Sultan ML, Hussain SS. Basic hematological derangement in heroin addicts. Pak J Med Res 1995:34(3):194–5.
21. Whitehead TP, Robinson D, Allaway SL, Hale AC. The effects of cigarette smoking and alcohol consumption on blood haemoglobin, erythrocytes and leucocytes: a dose related study on male subjects. Clin Lab Haematol 1995;17(2):131–8.
22. Bury G, O’Kelly, Pomeroy L. The use of primary care services by drug users attending an HIV prevention unit. Irish Med J 1993;86:53–5.
23. Zelvin S, Saunders S, Gourlay SG, Jacob P, Benowitz NL. Cardiovascular effects of carbon monoxide and cigarette smoking. J Am Coll Cardinol 2001;38(6):1633–8.
24. Cameron AJ. Heroin Addicts in a Casualty Department. BMJ 1964;1(5383):594–8.
25. Qureshi SA, Tayyab M. Acquired Immuno-deficiency Syndrome as an autoimmune disease. Postgrad Med J 1990;1:101.
26. Helman N, Rubenstein LS. The effects of age, sex and smoking on erythrocytes and leucocytes, Am J Clin Pathol 1975;63(1):35–44.


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Tariq M, Sultana R, Haq A. ERYTHROCYTES INDICES IN MALE SMOKERS AND HEROIN ADDICTS. PJP [Internet]. 31Dec.2013 [cited 21Feb.2020];9(2):32-4. Available from: