RELATIONSHIP OF SERUM RESISTIN AND LIPID PROFILE IN TYPE 2 DIABETICS
Background: Resistin an adipocyte derived factor has cysteine-rich C-terminal domain and has emerged as controversial link between obesity and type 2 diabetes mellitus (T2DM) in different studies and leads to dyslipidemia. This study was designed to determine and compare serum resistin, LDL and HDL levels in non-obese and obese type 2 diabetics. Methods: It was a cross-sectional analytical study in which eighty diabetic patients were recruited and were divided into two groups non-obese and obese on the basis of body mass index (BMI) and waist circumference (WC) (BMI ≤23, WC <90 Cm in group I and BMI ≥25, WC >90 Cm in group II). Serum resistin was measured by commercially available ELISA Kit. Serum LDL and HDL levels were measured by direct quantitative measurement. Results: Higher serum resistin and LDL, and lower serum HDL levels were recorded in obese diabetics compared to non-obese diabetics. Significant positive correlation of serum resistin with LDL and negative correlation between serum resistin and HDL was present in all type 2 diabetics. Conclusions: The positive correlation of serum resistin with serum LDL and negative correlation with serum HDL suggests serum resistin to be a link between obesity and T2DM and it may be responsible for altering lipid profile.
Keywords: Type 2 diabetes mellitus, serum, resistin, obesity, BMI, HDL, LDL, dyslipidemia
Pak J Physiol 2017;13(2):3–5
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