RELATIONSHIP OF SERUM RESISTIN AND LIPID PROFILE IN TYPE 2 DIABETICS

  • Abida Akhtar Lahore Medial and Dental College, Lahore, Pakistan
  • Muniza Saeed
  • Qammar Shakoor

Abstract

Background: Resistin an adipocyte derived factor has cysteine-rich C-terminal domain and has emerged as controversial link between obesity and type 2 diabetes mellitus (T2DM) in different studies and leads to dyslipidemia. This study was designed to determine and compare serum resistin, LDL and HDL levels in non-obese and obese type 2 diabetics. Methods: It was a cross-sectional analytical study in which eighty diabetic patients were recruited and were divided into two groups non-obese and obese on the basis of body mass index (BMI) and waist circumference (WC) (BMI ≤23, WC <90 Cm in group I and BMI ≥25, WC >90 Cm in group II). Serum resistin was measured by commercially available ELISA Kit. Serum LDL and HDL levels were measured by direct quantitative measurement. Results: Higher serum resistin and LDL, and lower serum HDL levels were recorded in obese diabetics compared to non-obese diabetics. Significant positive correlation of serum resistin with LDL and negative correlation between serum resistin and HDL was present in all type 2 diabetics. Conclusions: The positive correlation of serum resistin with serum LDL and negative correlation with serum HDL suggests serum resistin to be a link between obesity and T2DM and it may be responsible for altering lipid profile.


Keywords: Type 2 diabetes mellitus, serum, resistin, obesity, BMI, HDL, LDL, dyslipidemia


Pak J Physiol 2017;13(2):3–5

Author Biography

Abida Akhtar, Lahore Medial and Dental College, Lahore, Pakistan

Department of Physiology, Lahore Medial and Dental College, Lahore, Pakistan.

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Published
2017-12-29
How to Cite
AKHTAR, Abida; SAEED, Muniza; SHAKOOR, Qammar. RELATIONSHIP OF SERUM RESISTIN AND LIPID PROFILE IN TYPE 2 DIABETICS. Pakistan Journal of Physiology, [S.l.], v. 13, n. 2, p. 3-5, dec. 2017. ISSN 2073-1183. Available at: <http://pjp.pps.org.pk/index.php/PJP/article/view/36>. Date accessed: 20 apr. 2018.

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