• Abida Akhtar Lahore Medial and Dental College, Lahore, Pakistan
  • Muniza Saeed
  • Qammar Shakoor


Background: Resistin an adipocyte derived factor has cysteine-rich C-terminal domain and has emerged as controversial link between obesity and type 2 diabetes mellitus (T2DM) in different studies and leads to dyslipidemia. This study was designed to determine and compare serum resistin, LDL and HDL levels in non-obese and obese type 2 diabetics. Methods: It was a cross-sectional analytical study in which eighty diabetic patients were recruited and were divided into two groups non-obese and obese on the basis of body mass index (BMI) and waist circumference (WC) (BMI ≤23, WC <90 Cm in group I and BMI ≥25, WC >90 Cm in group II). Serum resistin was measured by commercially available ELISA Kit. Serum LDL and HDL levels were measured by direct quantitative measurement. Results: Higher serum resistin and LDL, and lower serum HDL levels were recorded in obese diabetics compared to non-obese diabetics. Significant positive correlation of serum resistin with LDL and negative correlation between serum resistin and HDL was present in all type 2 diabetics. Conclusions: The positive correlation of serum resistin with serum LDL and negative correlation with serum HDL suggests serum resistin to be a link between obesity and T2DM and it may be responsible for altering lipid profile.

Keywords: Type 2 diabetes mellitus, serum, resistin, obesity, BMI, HDL, LDL, dyslipidemia

Pak J Physiol 2017;13(2):3–5

Author Biography

Abida Akhtar, Lahore Medial and Dental College, Lahore, Pakistan

Department of Physiology, Lahore Medial and Dental College, Lahore, Pakistan.


1. Hakeem R, Fawwad A. Diabetes in Pakistan: Epidemiology, determinants and prevention. J Diabetology 2010;3:4.
2. Humayun A, Sher Shah A, Alam S, Hussein H. Relationship of body mass index and dyslipidemia in different age groups of male and female population of Peshawar. J Ayub Med Coll Abbottabad 2009;21(2):141–4.
3. Gastaldelli A, Cusi K, Petiti M, Hardies J, Miyazaki Y, Berria R, et al. Relationship between hepatic/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjects. Gastroenterology 2007;133:496–506.
4. Dong-Feng L, Han-dong Y, Bo Y, Tian-jun T, Xin-wen M, Yi L, et al. Relationship of the serum resistin level, lipid level, obesity and insulin resistance in patients with metabolic syndrome. J Chinese Clin Med 2007;8(2):1–6.
5. Benerjee RR, Lazar MA. Resistin: molecular history and prognosis. J Mol Med (Berl) 2003;81(4):218–26.
6. Lee JH, Chan JL, Yiannakouris N, Kontogianni M, Estrada E, Seip R, et al. Circulating resistin levels are not associated with obesity or insulin resistance in humans and are not regulated by fasting or leptin administration: Cross-sectional and interventional study in normal, insulin resistant and diabetic subjects. J Clin Endocrinol Metabol 2003;88(10):4848–56.
7. Mohammadzadeh G, Zarghami N, Mobaseri M. Serum resistin concentration in obese diabetic patients: any possible relation to insulin resistance indices? Int J Endocrinol Metab 2008;4(6):183–93.
8. Al-Harithy RN, Al-Ghamdi S. Serum resistin, adiposity and insulin resistance in Saudi women with type 2 diabetes mellitus. Ann Saudi Med 2005;25(4):283–7.
9. DeLuis DA, Sagrado MG, Conde R, Aller R, Izaola O. Resistin levels and inflammatory markers in patients with morbid obesity. Nutr Hosp 2010;25(4):630–4.
10. Azuma K, Katsukawa F, Oguchi S, Murata M, Yamazaki H, Shimada A, et al. Correlation between serum resistin level and adiposity in obese individuals. Obes Res 2003;11(8):997–1001.
11. Satoh H, Nguyen MT, Miles PD, Immamura T, Usui I, Olefsky JM. Adenovirus-mediated chronic hyper resistinemia leads to in vivo insulin resistance in normal rats. J Clin Investig 2004;114: 224–31.
12. Zhang J, Qin Y, Zheng X, Qiu J, Gong L, Mao H, et al. The relationship between human serum resistin level and body fat content, plasma glucose as well as blood pressure. Zonghua Yi Xue Za Zhi 2002;82(23):1609–12.
13. Chen BH, Yiging S, Ding EL, Robert LK, Manson JE, Rifai N, et al. Circulating levels of resistin and risk of type 2 diabetics in men and women: Results from two prospective cohorts. Diabetes Care 2009;32(2):329–34.
14. DeLuis DA, Sagrado MG, Conde R, Aller R, Izaola O. Resistin levels and inflammatory markers in patients with morbid obesity. Nutr Hosp 2010;25(4):630–4
15. Al-Daghri N, Chetty R, McTernan PG, Al-Rubean K, Al-Attas O, Jones AF, et al. Serum resistin is associated with C-reactive protein and LDL cholesterol in type 2 diabetes and coronary artery disease in a Saudi population. Cardiovasc Diabetol 2005;4:1–10.
16. Al-Sari IE, Al-quobaili FA, Kabalan YM. Serum resistin levels in Syrian obese patients with diabetes mellitus type II. Saudi Med J 2007;28(12):1890–4.
17. Bitzur R, Cohen H, Kamari Y, Shaish A, Harats D. Triglycerides and HDL cholesterol: Stars or second leads in diabetes? Diabetes Care 2009;32(2):373–7.
How to Cite
AKHTAR, Abida; SAEED, Muniza; SHAKOOR, Qammar. RELATIONSHIP OF SERUM RESISTIN AND LIPID PROFILE IN TYPE 2 DIABETICS. Pakistan Journal of Physiology, [S.l.], v. 13, n. 2, p. 3-5, dec. 2017. ISSN 2073-1183. Available at: <>. Date accessed: 22 jan. 2018.

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