EFFECT OF CIRCADIAN RHYTHM ON THE BLOOD PRESSURE ADJUSTMENT IN RESPONSE TO A PHYSICAL STRESS

Authors

  • Muhammad Tariq Aftab Professor of Pharmacology and Therapeutics, Karachi Medical and Dental College, Karachi, Pakistan
  • Nimrah Miraj Department of Pharmacology & Therapeutics, Karachi Medical and Dental College, Karachi, Pakistan
  • Sobia Masood Department of Pharmacology & Therapeutics, Karachi Medical and Dental College, Karachi, Pakistan
  • Sehba Shamim Department of Pharmacology & Therapeutics, Karachi Medical and Dental College, Karachi, Pakistan
  • Shafaq Fayyaz Department of Pharmacology & Therapeutics, Karachi Medical and Dental College, Karachi, Pakistan

Keywords:

Circadian Rhythm, Blood Pressure, Physical Stress, Blood Pressure control

Abstract

Background: Many studies have shown a relationship between circadian rhythm and certain physiological functions and pathological changes in the body. Blood pressure is highly sensitive in this regard. The role of circadian rhythm in controlling the blood pressure requires further exploration. This study was conducted to investigate variability of blood pressure adjustment due to circadian rhythm after a physical stress. Method: Data was collected from 29 undergraduate students after consent and briefing them the nature and purpose of the study. Blood pressure changes in the morning and afternoon after same physical stress were noted. Result: It was found that circadian rhythm has significant effect (p<0.05) on systolic and diastolic blood pressures in the morning (from 8 to 9 AM) and afternoon (from 2 to 3 PM). This difference becomes insignificant (p>0.05) in these two phases of the day due to larger changes (p<0.05) in these two parameters by same exercise. But after five minutes the adjustment of systolic and diastolic Blood pressures in so effective that a significant (p<0.05) difference is again retained in the systolic and diastolic blood pressures. Conclusion: The blood pressure controlling mechanism becomes more responsive with circadian rhythm to control the larger changes of blood pressure effectively.

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References

1. Duffy JF, Wright KP Jr. Entrainment of the human circadian system by light. J Biol Rhythms 2005;20(4):326–38.
2. Czeisler CA. The effect of light on the human circadian pacemaker. Ciba Found Symp 1995;183:254–90.
3. Figueiro MG, Rea MS. Lack of short-wavelength light during the school day delays dim light melatonin onset (DLMO) in middle school students Neuro Endocrinol Lett 2010;31(1):4.
4. Dodt C, Breckling U, Derad I, Fehm HL, Born J. Plasma epinephrine and norepinephrine concentrations of healthy humans associated with night time sleep and morning arousal. Hypertension 1997;30:71–6.
5. Franken P, Lopez-Molina L, Marcacci L, Schibler U, Tafti M. The transcription factor DBP affects circadian sleep consolidation and rhythmic EEG activity. J Neurosci 2000;20(2):617–25.
6. Broughton R, Baron R. Sleep patterns in the intensive care unit and on the ward after acute myocardial infarction. Electroencephalogr Clin Neurophysiol 1978;45(3):348–60.
7. Millar-Craig MW, Bishop CN, Raftery EB. Circadian variation of blood pressure. Lancet 1978;1:795–7.
8. White WB. Circadian variation in blood pressure. Blood Press Monit 1997;2:46–51.
9. Kumar P, Clark M. Practical Box 11.1, Taking the Blood pressure; Cardiovascular disease in Clinical Medicine. 4th ed. WB Saunders, 1998. p. 634.
10. Hermida RC, Ayala DE, Fernandez JR, Portaluppi F, Fabbian F, Smolensky MH. Circadian rhythms in blood pressure regulation and optimization of hypertension treatment with ACE inhibitor and ARB medications. Am J Hypertens 2011;24(4):383–91.
11. Baumgart P. Circadian rhythm of blood pressure internal and external time triggers. Chronobiol Intern 1991;8:444.
12. Glisezinki ID, Larrouy D, Bajzova M, Koppo K, Polak J, Berlan M, et al. Adrenaline but not noradrenaline is a determinant of exercise-induced lipid mobilization in human subcutaneous adipose tissue. J Physiol 2009;587(Pt 13):3393–404.
13. Hu K, Scheer FA, Laker M, Smales C, Shea SA. Endogenous circadian rhythm in vasovagal response to head-up tilt. Circulation 2011;123(9):961–70.
14. Scheer FA, Hu K, Evoniuk H, Kelly EE, Malhotra A, Hilton MF, et al. Impact of the human circadian system, exercise, and their interaction on cardiovascular function. Proc Natl Acad Sci 2010;107(47):20541–6.

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Published

30-06-2013

How to Cite

1.
Aftab MT, Miraj N, Masood S, Shamim S, Fayyaz S. EFFECT OF CIRCADIAN RHYTHM ON THE BLOOD PRESSURE ADJUSTMENT IN RESPONSE TO A PHYSICAL STRESS. Pak J Phsyiol [Internet]. 2013 Jun. 30 [cited 2024 Mar. 28];9(1):26-8. Available from: https://pjp.pps.org.pk/index.php/PJP/article/view/323