CORRELATION OF SIGNAL AVERAGED ECG PARAMETERS WITH LEFT VENTRICULAR MASS INDEX IN PATIENTS WITH SYSTEMIC ARTERIAL HYPERTENSION

  • Bushra Riaz Department of Physiology, Army Medical College, Rawalpindi, Pakistan
  • Muhammad Alamgir Khan Department of Physiology, Army Medical College, Rawalpindi
  • Humaira Ali Department of Physiology, HITEC Institute of Medical Sciences, Taxila Cantt.
  • Syed Muhammad Imran Majeed National University of Medical Sciences, Rawalpindi
Keywords: Ventricular late potentials, Signal averaged ECG, Systemic arterial hypertension, Left ventricular mass index, ECG

Abstract

Background: Signal averaged ECG is a high-resolution electrocardiography which detects ventricular late potentials in patients susceptible to ventricular arrhythmias. Ventricular late potentials are identified on the basis of three parameters detected on signal averaged ECG. This study was planned to determine the correlation of signal averaged ECG parameters with left ventricular mass index in hypertensive patients. Methods: Sixty-four patients with systemic arterial hypertension were enrolled in the study. Patients with acute or old myocardial infarction, diabetes mellitus, cerebrovascular accident, heart failure, structural heart disease, bundle branch block and cardiomyopathies were excluded. Holter monitors (DMS 300 4L) were used to obtain 3 channel signal averaged ECG recording. CardioScan premium luxury software was used for analysis of ventricular late potentials. Results: There were 49 (76.6%) males and 15 (23.4%) female patients (n=64) with mean age of 60±11.83 years. Eleven patients (17.2%) had ventricular late potentials whereas 53 (82.8%) were without them. The mean values for filtered QRS complex, low amplitude signals, root mean square voltage, noise and left ventricular mass index were 108.52±23.63 ms, 28.81±20.78 ms, 92.17±51.02 µv, 0.29±0.26 µv and 140.48±68.26 g/m2 respectively. Left ventricular mass index was significantly and positively correlated with filtered QRS complex (p<0.001) and low amplitude signals (p=0.03) whereas the correlation with root means square voltage was not significant (p=0.84). Left ventricular mass index had significant and positive correlation with ventricular late potentials (p=0.009). Conclusion: Patients with higher left ventricular mass index are at greater risk of developing ventricular late potentials which are reflective of ventricular arrhythmias. In hypertensive patients with increased left ventricular mass index the arrhythmogenesis seems to be more related to duration of the cardiac signal as compared to its voltage.

Keywords: Ventricular late potentials, signal averaged ECG, systemic arterial hypertension, left ventricular mass index

Pak J Physiol 2018;14(1):19–22

Author Biographies

Bushra Riaz, Department of Physiology, Army Medical College, Rawalpindi, Pakistan

Department of Physiology, Army Medical College, Rawalpindi, Pakistan

Muhammad Alamgir Khan, Department of Physiology, Army Medical College, Rawalpindi

Professor of Physiology, Army Medical College, Abid Majid Road, Rawalpindi

Humaira Ali, Department of Physiology, HITEC Institute of Medical Sciences, Taxila Cantt.

Department of Physiology, HITEC Institute of Medical Sciences, Taxila Cantt.

Syed Muhammad Imran Majeed, National University of Medical Sciences, Rawalpindi

National University of Medical Sciences, Rawalpindi

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Published
2018-03-31
How to Cite
1.
Riaz B, Khan M, Ali H, Majeed S. CORRELATION OF SIGNAL AVERAGED ECG PARAMETERS WITH LEFT VENTRICULAR MASS INDEX IN PATIENTS WITH SYSTEMIC ARTERIAL HYPERTENSION. PJP [Internet]. 31Mar.2018 [cited 19Oct.2018];14(1):19-2. Available from: http://pjp.pps.org.pk/index.php/PJP/article/view/155

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