PROTECTIVE ROLE OF TURMERIC ON BIOCHEMICAL PARAMETERS OF LIVER IN NIMESULIDE INDUCED HEPATIC INJURY IN RATS
Background: Damage to hepatocytes, e.g., necrosis, inflammation and degenerative disease causes release of liver enzymes into the circulation and they are measured both for diagnosis and prognosis of disease. The objective of this study was to see the protective effect of turmeric powder on liver enzymes against Nimesulide-induced hepatic injury in rat model. Methods: Forty (40) male albino Wistar rats were divided into four groups. In group A, normal diet was given for 9 days while in group B, Nimesulide was given for 9 days followed by turmeric powder for next 9 days; while turmeric powder for 9 days followed by Nimesulide for next 9 days was used in group C. Group D received Nimesulide in adjunct with Turmeric powder for 9 days. After 24 hours of feeding, Blood samples from groups A and D were taken for biochemical analysis of serum levels of ALT, AST, Alkaline Phosphatase and γ-GT at days 0 and 9. For groups B and C blood samples were collected at day 1, day 9 and day 18. The results were statistically analyzed by using SPSS-21 and Statistix 8.1. Results: In control group A, the results were found almost same on day 1 and 9. The group B shows a high value on day 9 in comparison to day 1, but after treatment with turmeric there is a marked reduction towards normal in all parameters on day 18. The group C show initially reduction in the values of all parameter on day 9 after taking the turmeric powder but there is an incline after taking Nimesulide. The group D received Nimesulide in adjunct with Turmeric powder for 9 days show slight increase in the results from day 1 in all parameters. The results were found significant (p<0.05) in the three treated groups. Conclusion: Turmeric has hepatoprotective properties against hepatotoxicity produced by Nimesulide.
Keywords: Turmeric, Hepatic injury, LFTs, Nimesulide, Enzymes, Hepatotoxicity
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