IRON STATUS BASED ON BLOOD TRANSFUSIONS IN PATIENTS ON HEMODIALYSIS

  • Muhammad Bilal Ghafoor Department of Pathology, Sheikh Zayed Medical College/Hospital, Rahim Yar Khan, Pakistan
  • Ali Gul Tunio Department of Pharmacology, Shaheed Muhtarma Benazir Bhutto Medical University, Larkana, Pakistan
  • Mazhar Hussain Department of Pharmacology, Sheikh Zayed Medical College/Hospital, Rahim Yar Khan, Pakistan
  • Maryam Zahid Department of Pathology, Sheikh Zayed Medical College/Hospital, Rahim Yar Khan, Pakistan
  • Ghulam Serwar Department of Biochemistry, Shaheed Muhtarma Benazir Bhutto Medical University, Larkana, Pakistan
Keywords: Iron Status, Iron stores, TIBC, Ferritin, Haemodialysis, Chronic kidney disease, Renal failure, Transfusion

Abstract

Background: Multiple blood transfusions and iron therapies leads to iron overload and may lead to deposition of iron in liver. This study was carried out to determine the iron levels based on the frequency of blood transfusions in patients of chronic kidney disease on haemodialysis. Methods: In this descriptive study, total 85 chronic renal failure patients were enrolled and compared with control groups. Patients were divided into two groups on the basis of blood transfusions received. The collected blood samples were centrifuged (5,000 rpm for 10 min) and serum was assessed for Serum ferritin, Serum iron, Serum TIBC by Chemiluminescence assay. Results: The prevalence of serum iron and serum ferritin level in haemodialysis patients was significantly higher compared to control group (p=0.002 and p=0.001 respectively). On the other hand value of TIBC and transferrin saturation was significantly lower in comparison with control (p=0.006 and 0.002 respectively). Similarly there was increase in serum iron and ferritin level in haemodialysis patients who received more than 2 or multiple blood transfusions as compared to less than 2 blood transfusions. (p=0.006 and 0.001 respectively). This increase was further accompanied by decrease in TIBC and transferrin saturation in more than 2 or multiple blood transfusion patients vs less than 2 blood transfusions (p=0.007 and 0.002 respectively). No significant changes were noted in these parameters with respect to gender in case group. Conclusion: Most of the patients on haemodialysis have increased iron store in the form of ferritin.

Pak J Physiol 2019;15(1):29–31  

Author Biographies

Muhammad Bilal Ghafoor, Department of Pathology, Sheikh Zayed Medical College/Hospital, Rahim Yar Khan, Pakistan

Department of Pathology,

Sheikh Zayed Medical College/Hospital,

Rahim Yar Khan, Pakistan

Ali Gul Tunio, Department of Pharmacology, Shaheed Muhtarma Benazir Bhutto Medical University, Larkana, Pakistan

Department of Pharmacology,

Shaheed Muhtarma Benazir Bhutto Medical University,

Larkana, Pakistan

Mazhar Hussain, Department of Pharmacology, Sheikh Zayed Medical College/Hospital, Rahim Yar Khan, Pakistan

Department of Pharmacology,

Sheikh Zayed Medical College/Hospital,

Rahim Yar Khan, Pakistan

Maryam Zahid, Department of Pathology, Sheikh Zayed Medical College/Hospital, Rahim Yar Khan, Pakistan

Department of Pathology,

Sheikh Zayed Medical College/Hospital,

Rahim Yar Khan, Pakistan

Ghulam Serwar, Department of Biochemistry, Shaheed Muhtarma Benazir Bhutto Medical University, Larkana, Pakistan

Department of Biochemistry,

Shaheed Muhtarma Benazir Bhutto Medical University,

Larkana, Pakistan

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Published
2019-03-31
How to Cite
1.
Ghafoor M, Tunio A, Hussain M, Zahid M, Serwar G. IRON STATUS BASED ON BLOOD TRANSFUSIONS IN PATIENTS ON HEMODIALYSIS. PJP [Internet]. 31Mar.2019 [cited 16Jul.2019];15(1):29-1. Available from: http://pjp.pps.org.pk/index.php/PJP/article/view/143