ROLE OF TRPM6 AND TRPM7 GENE POLYMORPHISMS IN RHEUMATOID ARTHRITIS: A SYSTEMATIC REVIEW

  • Shahid Fareed Accident and Emergency Department, Lady Reading Hospital, Peshawar
  • Shah Hussain Accident and Emergency Department, Lady Reading Hospital, Peshawar.
  • Farooq Khan Department of Anatomy, Peshawar Medical College, Peshawar
  • Jehan Badshah Emergency Department, Lady Reading Hospital, Peshawar.
  • Fateh ur Rehman Rufaidah Nursing College, Peshawar.
  • Mohsin Ali Muhammad College of Medicine, Peshawar, Pakistan
Keywords: Rheumatoid arthritis, TRPM6, TRPM7, Peshawar, hypomagnesemia, Arthritis, Magnesium, Polymorphism

Abstract

Rheumatoid arthritis (RA) is a type of the autoimmune disease that adversely effects on the quality of life of the patient, primarily by affecting the joints. Different underlying immune system diseases through a common pathway may proceed to onset of rheumatoid arthritis. Magnesium (Mg) is one of the other essential minerals having significant role in the management of normal immune responses in inflammatory conditions. The exact role of magnesium deficiency (MgD) in pathophysiology of rheumatoid arthritis is still under debate, but several mechanisms are proposed through which, MgD leads to generation of inappropriate immune system functions. Most of the dietary Mg is absorbed in small intestine through paracellular passive mechanism while small amount is transported in blood through Transient Receptor Potential Channel Melastatin member 6 and 7 (TRPM6 and TRPM7). Genetic alterations in TRPM gene results in hypomagnesaemia, which may in turn, increase the risk of onset of pro-inflammatory mediators.

Pak J Physiol 2022;18(1):63–7

References

Hayter SM, Cook MC. Updated assessment of the prevalence, spectrum and case definition of autoimmune disease. Autoimmun Rev 2012;11(10):754–65.

Watad A, Bragazzi NL, Adawi M, Amital H, Toubi E, Porat BS, et al. Autoimmunity in the elderly: insights from basic science and clinics-a mini-review. Gerontology 2017;63(6):515–23.

Parish LC. An historical approach to the nomenclature of rheumatoid arthritis. Arthritis Rheum 1963;6(2):138–58.

Mallia C, Coleiro B. Understanding rheumatoid arthritis. In: Grech L, Lau A. (Eds). Pharmaceutical care issues of patients with rheumatoid arthritis: Springer; 2016.p. 1–18.

Derksen VFAM, Huizinga TWJ, van der Woude D. The role of autoantibodies in the pathophysiology of rheumatoid arthritis. Semin Immunopathol 2017;39(4):437–46..

de Brito Rocha S, Baldo DC, Andrade LEC. Clinical and pathophysiologic relevance of autoantibodies in rheumatoid arthritis. Adv Rheumatol 2019;59(1):2.

Edilova MI, Akram A, Abdul-Sater AA. Innate immunity drives pathogenesis of rheumatoid arthritis. Biomed J 2021;44(2):172–82.

Blaine J, Chonchol M, Levi M. Renal control of calcium, phosphate, and magnesium homeostasis. Clin J Am Soc Nephrol 2015;10(7):1257–72.

Mazur A, Maier JA, Rock E, Gueux E, Nowacki W, Rayssiguier Y. Magnesium and the inflammatory response: potential physiopathological implications. Arch Biochem Biophys 2007;458(1):48–56.

Nielsen FH. Magnesium deficiency and increased inflammation: current perspectives. J Inflamm Res 2018;11:25–34.

Maier JA, Castiglioni S, Locatelli L, Zocchi M, Mazur A. Magnesium and inflammation: Advances and perspectives. Semin Cell Dev Biol 2021;115:37–44.

Volpe SL. Magnesium in disease prevention and overall health. Adv Nutr 2013;4(3):378S–83S.

de Baaij JH, Hoenderop JG, Bindels RJ. Regulation of magnesium balance: lessons learned from human genetic disease. Clin Kidney J 2012;5(Suppl_1):i15–24.

Schuchardt PJ, Hahn A. Intestinal absorption and factors influencing bioavailability of magnesium-an update. Curr Nutr Food Sci 2017;13(4):260–78.

Schweigel M, Martens H. Magnesium transport in the gastrointestinal tract. Front Biosci 2000;5(3):D666–77.

Broeren MA, Geerdink EA, Vader HL, van den Wall Bake AW. Hypomagnesemia induced by several proton-pump inhibitors. Ann Intern Med 2009;151(10):755–6.

Luongo F, Pietropaolo G, Gautier M, Dhennin-Duthille I, Ouadid-Ahidouch H, Wolf FI, et al. TRPM6 is essential for magnesium uptake and epithelial cell function in the colon. Nutrients 2018;10(6):784.

Lainez S, Schlingmann KP, van der Wijst J, Dworniczak B, van Zeeland F, Konrad M, et al. New TRPM6 missense mutations linked to hypomagnesemia with secondary hypocalcemia. Eur Hum Genet 2014;22(4):497–504.

Coulter M, Colvin C, Korf B, Messiaen L, Tuanama B, Crowley M, et al. Hypomagnesemia due to two novel TRPM6 mutations. J Pediatr Endocrinol Metab 2015;28(11–12):1373–8.

Rexrode KM, Lee IM, Cook NR, Hennekens CH, Buring JE. Baseline characteristics of participants in the women’s health study. J Womens Health Gend Based Med 2000;9(1):19–27.

Zierler S, Hampe S, Nadolni W. TRPM channels as potential therapeutic targets against pro-inflammatory diseases. Cell Calcium 2017;67:105–15.

Corre T, Arjona FJ, Hayward C, Youhanna S, de Baaij JH, Belge H, et al. Genome-wide meta-analysis unravels interactions between magnesium homeostasis and metabolic phenotypes. J Am Soc Nephrol 2018;29(1):335–48.

Schlingmann KP, Sassen MC, Weber S, Pechmann U, Kusch K, Pelken L, et al. Novel TRPM6 mutations in 21 families with primary hypomagnesemia and secondary hypocalcemia. J Am Soc Nephrol 2005;16(10):3061–9.

Cheng WW, Zhu Q, Zhang HY. Mineral nutrition and the risk of chronic diseases: a Mendelian randomization study. Nutrients 2019;11(2):378.

Dai Q, Shrubsole MJ, Ness RM, Schlundt D, Cai Q, Smalley WE, et al. The relation of magnesium and calcium intakes and a genetic polymorphism in the magnesium transporter to colorectal neoplasia risk. Am J Clin Nutr 2007;86(3):743–51.

Deng X, Shrubsole MJ, Ness RM, Cai Q, Zhu X, Smalley WE, et al. Abstract 4478: Erythrocyte magnesium, TRPM7 Thr1482Ile polymorphism, and colorectal adenoma risk. In: Epidemiology. American Association for Cancer Research; 2012.p. 4478.

Trapani V, Arduini D, Cittadini A, Wolf FI. From magnesium to magnesium transporters in cancer: TRPM7, a novel signature in tumour development. Magnes Res 2013;26(4):149–55.

Hashizume N, Mori M. An analysis of hypermagnesemia and hypomagnesemia. Jap J Med 1990;29(4):368–72.

Chavan VU, Ramavataram D, Patel PA, Rupani MP. Evaluation of serum magnesium, lipid profile and various biochemical parameters as risk factors of cardiovascular diseases in patients with rheumatoid arthritis. J Clin Diagn Res 2015;9(4):BC01–5.

Kremer JM, Bigaouette J. Nutrient intake of patients with rheumatoid arthritis is deficient in pyridoxine, zinc, copper, and magnesium. J Rheumatol 1996;23(6):990–4.

Tuncer S, Kamanli A, Akçil E, Kavas GO, Seçkin B, Atay MB. Trace element and magnesium levels and superoxide dismutase activity in rheumatoid arthritis. Biol Trace Elem Res 1999;68(2):137–42.

Hansson L, Huunan-Seppala A, Mattila A. The content of calcium, magnesium, copper, zinc, lead and chromium in the blood of patients with rheumatoid arthritis. Scand J Rheumatol 1975;4(1):33–8.

Leipzig L, Boyle A, McCann D. Case histories of rheumatoid arthritis treated with sodium or magnesium EDTA. J Chronic Dis 1970;22(8):553–63.

Zeng C, Wei J, Li H, Yang T, Zhang FJ, Pan D, et al. Relationship between serum magnesium concentration and radiographic knee osteoarthritis. J Rheumatol 2015;42:1231–6.

Selmi C, Tsuneyama K. Nutrition, geoepidemiology, and autoimmunity. Autoimmun Rev 2010;9(5):A267–70.

Libako P, Nowacki W, Rock E, Rayssiguier Y, Mazur A. Phagocyte priming by low magnesium status: input to the enhanced inflammatory and oxidative stress responses. Magnes Res 2010;23(1):1–4.

Song Y, Hsu YH, Niu T, Manson JE, Buring JE, Liu S. Common genetic variants of the ion channel transient receptor potential membrane melastatin 6 and 7 (TRPM6 and TRPM7), magnesium intake, and risk of type 2 diabetes in women. BMC Med Genet 2009;10:4.

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Published
2022-03-31
How to Cite
1.
Fareed S, Hussain S, Khan F, Badshah J, Rehman F, Ali M. ROLE OF TRPM6 AND TRPM7 GENE POLYMORPHISMS IN RHEUMATOID ARTHRITIS: A SYSTEMATIC REVIEW. PJP [Internet]. 31Mar.2022 [cited 26Nov.2022];18(1):63-7. Available from: http://pjp.pps.org.pk/index.php/PJP/article/view/1365

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