• Shahid Fareed Accident and Emergency Department, Lady Reading Hospital, Peshawar
  • Shah Hussain Accident and Emergency Department, Lady Reading Hospital, Peshawar.
  • Farooq Khan Department of Anatomy, Peshawar Medical College, Peshawar
  • Jehan Badshah Emergency Department, Lady Reading Hospital, Peshawar.
  • Fateh ur Rehman Rufaidah Nursing College, Peshawar.
  • Mohsin Ali Muhammad College of Medicine, Peshawar, Pakistan
Keywords: Rheumatoid arthritis, TRPM6, TRPM7, Peshawar, hypomagnesemia, Arthritis, Magnesium, Polymorphism


Rheumatoid arthritis (RA) is a type of the autoimmune disease that adversely effects on the quality of life of the patient, primarily by affecting the joints. Different underlying immune system diseases through a common pathway may proceed to onset of rheumatoid arthritis. Magnesium (Mg) is one of the other essential minerals having significant role in the management of normal immune responses in inflammatory conditions. The exact role of magnesium deficiency (MgD) in pathophysiology of rheumatoid arthritis is still under debate, but several mechanisms are proposed through which, MgD leads to generation of inappropriate immune system functions. Most of the dietary Mg is absorbed in small intestine through paracellular passive mechanism while small amount is transported in blood through Transient Receptor Potential Channel Melastatin member 6 and 7 (TRPM6 and TRPM7). Genetic alterations in TRPM gene results in hypomagnesaemia, which may in turn, increase the risk of onset of pro-inflammatory mediators.

Pak J Physiol 2022;18(1):63–7


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Fareed S, Hussain S, Khan F, Badshah J, Rehman F, Ali M. ROLE OF TRPM6 AND TRPM7 GENE POLYMORPHISMS IN RHEUMATOID ARTHRITIS: A SYSTEMATIC REVIEW. PJP [Internet]. 31Mar.2022 [cited 26Nov.2022];18(1):63-7. Available from:

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