COMPARISON OF DIET INDUCED METABOLIC SYNDROME WITH ARTIFICIALLY INDUCED METABOLIC SYNDROME IN A RAT MODEL

  • Jawaria Ilyas Department of Physiology, Postgraduate Medical Institute/Ameer ud Din Medical College, Lahore, Pakistan
  • Noor Zahra Tehsil Headquarter Hospital, Sangla Hill, Nankana Sahib, Pakistan
  • Amer Hassan Siddique Department of Pharmacology, Postgraduate Medical Institute/Ameer ud Din Medical College, Lahore, Pakistan
  • Komal Iqbal Department of Physiology, Postgraduate Medical Institute/Ameer ud Din Medical College, Lahore, Pakistan
  • Rana Muhammad Yousaf Department of Physiology, Postgraduate Medical Institute/Ameer ud Din Medical College, Lahore, Pakistan
  • Muniza Saeed Department of Physiology, Postgraduate Medical Institute/Ameer ud Din Medical College, Lahore, Pakistan
Keywords: Metabolic syndrome, High fat high carbohydrate diet, Monosodium glutamate, Obesity, Hypertension, Dyslipidemia, Insulin resistance, Male SD rats

Abstract

Background: Metabolic syndrome is an emerging health problem. The diets rich in fats and refined carbohydrates and monosodium glutamate are considered major risk factors for this emerging epidemic. The aim of this study was to determine whether high fat high carbohydrate (HFHC) diet, Monosodium glutamate (MSG) diet or their combination is faster/more potent inducer of MS. Methods: Twenty male Sprague Dawley rats were randomly divided into four groups. Group 1 was given normal rat chow, group 2 was given HFHC diet, group 3 was given MSG in diet and group 4 was given both HFHC and MSG in their diet for 20 weeks. Body weight, blood pressure, lipid profile and glycaemic indices were determined at the end of study. Results: After 20 weeks of study, HFHC and MSG groups showed full blown Metabolic syndrome (MS) with development of obesity, hypertension, hyperglycaemia and dyslipidemia. However, group 4 which was given combination diet did not develop features of MS. Conclusion: Both HFHC and MSG containing diets when given alone are potent inducers of MS in rat model rather than their combination.

Pak J Physiol 2022;18(2):6‒9

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Published
2022-06-30
How to Cite
1.
Ilyas J, Zahra N, Siddique A, Iqbal K, Yousaf R, Saeed M. COMPARISON OF DIET INDUCED METABOLIC SYNDROME WITH ARTIFICIALLY INDUCED METABOLIC SYNDROME IN A RAT MODEL. PJP [Internet]. 30Jun.2022 [cited 26Nov.2022];18(2):6-. Available from: http://pjp.pps.org.pk/index.php/PJP/article/view/1330