Effectiveness of transdermal nitroglycerine compared to oral nifedipine in prevention of preterm labour

  • Bushra Bashir Gynaecology unit King Abdullah Teaching Hospital Mansehra, Pakistan
  • Maria Shafiq Department of Physiology, Ayub Medical College Abbottabad 
  • Aamir Nazir Department of Physiology, Ayub Medical College Abbottabad
  • Muhammad Adeel Alam Department of Pharmacology, Ayub Medical College Abbottabad.
  • Alruba Taimoor Department of Physiology, Ayub Medical College Abbottabad 
  • Bibi Munazza Department of Physiology, Ayub Medical College, Abbottabad, Pakistan
Keywords: Delivery, Spontaneous, Preterm, Labour, Nitroglycerine, Nifedipine

Abstract

Background: Preterm labour is a major complication of pregnancy associated with perinatal mortality and morbidity. Various drugs and strategies have been used for the treatment of preterm labour. The objective of this study was to compare the efficacy of transdermal nitroglycerine patch versus oral nifedipine in prevention of preterm labour. Methods: A randomized controlled trial was designed and conducted at the Department of Obstetrics/Gynaecology, Ayub Teaching Hospital, Abbottabad. The participants were randomly divided into 2 groups: the transdermal nitroglycerine group and oral nifedipine group with 63 participants in each group. Nitroglycerine transdermal patch of 5 mg was applied over the anterior abdominal wall in the first group and oral nifedipine was administered orally to second group. The efficacy in terms of delay in delivery by 48 hours was noted for each intervention and recorded in the proforma. Mean±SD were calculated for numerical variables. For the categorical variables, Chi-square (χ2) test was used, and p≤0.05 was considered as statistically significant. Results: Overall the given treatment was effective in 94 (75%) patients. In transdermal nitroglycerine group, the delay of delivery by 48 hours was found in 53 (85%) patients. In oral nifedipine group, delay of delivery by 48 hours was seen in 41 (65%) patients (p<0.05). Conclusion: Transdermal nitroglycerine patch is more effective to delay labour as compared to nifedipine. Therefore, it may be promisingly safe, effective, well-tolerated, cost-effective, and non-invasive method of tocolysis.

Pak J Physiol 2019;15(4):7−10

Author Biographies

Bushra Bashir, Gynaecology unit King Abdullah Teaching Hospital Mansehra, Pakistan

Gynaecology Department King Abdullah Teaching Hospital Mansehra

Muhammad Adeel Alam, Department of Pharmacology, Ayub Medical College Abbottabad.

Department of Pharmacology, Ayub Medical College Abbottabad.

Alruba Taimoor, Department of Physiology, Ayub Medical College Abbottabad 

Assistant Professor Department of Physiology, Ayub Medical College Abbottabad 

Bibi Munazza, Department of Physiology, Ayub Medical College, Abbottabad, Pakistan

Assiociate Proffessor  Ayub Medical College Abbottabad

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Published
2019-12-08
How to Cite
1.
Bashir B, Shafiq M, Nazir A, Alam M, Taimoor A, Munazza B. Effectiveness of transdermal nitroglycerine compared to oral nifedipine in prevention of preterm labour. PJP [Internet]. 8Dec.2019 [cited 10Apr.2020];15(4):7-0. Available from: http://pjp.pps.org.pk/index.php/PJP/article/view/1113

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