Serum resistin levels as prognostic marker in pulmonary tuberculosis
Background: Resistin targets various human cells and induces inflammation and autoimmune processes by promoting the release of multiple proinflammatory cytokines. The objective of this study was to determine the importance of serum resistin levels as prognostic biomarker in patients on antituberculous therapy. Methodology: This prospective cohort study was conducted in Military Hospital, and Army Medical College, Rawalpindi. The study recruited 90 patients by convenience sampling, divided into 2 equal groups comprising of active tuberculous patients and healthy controls. After written informed consent their blood samples were taken at various events (0, 2 and 4 months) and were assessed for serum resistin levels measured via ELISA. Results: The serum resistin levels were raised (43±16 ηg/mL) significantly in cases at time of diagnosis, when compared with healthy controls (10±2 ηg/mL). After 2nd and 4th month of treatment the levels were 15±10 ηg/mL and 22±10 ηg/mL respectively. The serum resistin level declined significantly over both events (p<0.01). Conclusion: Serum Resistin levels were increased at time of diagnosis in tuberculous patients and declined significantly during therapy.
Pak J Physiol 2019;15(3):60−2
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