EFFECTS OF INTERLEUKIN 1 INHIBITOR ON INFLAMMATORY CYTOKINES TNF-ALPHA LEVELS IN DIABETIC ALBINO WISTAR RAT MODEL

  • Roomi Aijaz Memon Isra university, Hyderabad, Pakistan
  • Navaid Kazi Isra university, Hyderabad, Pakistan
  • Arsalan Uquili Isra university, Hyderabad, Pakistan
  • Hinna Memon Isra university, Hyderabad, Pakistan
  • Aijaz Ali Memon Isra university, Hyderabad, Pakistan
Keywords: Interleukin-1 inhibitor, Alloxan, Diabetes Mellitus, TNF-α

Abstract

Background: Diacerein is a second generation Interleukin-1 inhibitor (IL-1). IL-1 and Tumour Necrosis Factor Alpha (TNF-α), are inhibitors of the pancreatic β-cells secretory activity and proliferation. There is need to test Diacerein on IL-1-TNF-α axis to improves the β-cell functions and proliferation. This study was designed to determine the relation of inflammatory markers and diabetes mellitus in interleukin 1 inhibitors treated albino Wistar rat models. Methods: A sample of 60 albino Wistar rats, selected by convenient purposive sampling, was divided into 4 groups: Group A (Controls), Group B (given Alloxan 50 mg/Kg, i.p.), Group C (Diabetic rats given Diacerein 30 mg/Kg for 21 days) and Group D (Diabetic rats given Diacerein 50 mg/Kg for 21 days).  The data was analyzed using SPSS-22. Results: The Mean±SD of blood glucose in the groups A, B, C, and D was noted as 113.66±10.67, 253.19±63.71, 215.23±36.32 and 178.0±16.52 mg/dl respectively (F=36.77, p=0.010). The Mean±SD of HbA1c in the groups A, B, C and D was noted as 4.14±0.86, 9.85±0.97, 7.52±0.78 and 6.71±1.02 mg/dl respectively (F=69.58, p=0.018). The Mean±SD of TNF-α in the groups A, B, C, and D was noted as 14.99±4.14, 37.85±3.61, 32.74±4.09, and 26.24±2.64 mg/dl respectively. Conclusion: Our findings suggested that inflammatory markers (TNF-α) were decrease and good glycaemic control   with interleukin 1 inhibitors (Diacerein) treated diabetic rats.

Keywords: Interleukin-1 inhibitor, Alloxan, Diabetes Mellitus, TNF-α

Pak J Physiol 2019;15(1):3–6

Author Biographies

Roomi Aijaz Memon, Isra university, Hyderabad, Pakistan

Department of Physiology,

Isra University Hyderabad, Pakistan.

Navaid Kazi, Isra university, Hyderabad, Pakistan

Department of Physiology,

Isra University Hyderabad, Pakistan

Arsalan Uquili, Isra university, Hyderabad, Pakistan

Department of Physiology,

Isra University Hyderabad, Pakistan

Hinna Memon, Isra university, Hyderabad, Pakistan

Department of Physiology,

Isra University Hyderabad, Pakistan

Aijaz Ali Memon, Isra university, Hyderabad, Pakistan

Department of Physiology,

Isra University Hyderabad, Pakistan

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Published
2019-03-31
How to Cite
1.
Memon R, Kazi N, Uquili A, Memon H, Memon A. EFFECTS OF INTERLEUKIN 1 INHIBITOR ON INFLAMMATORY CYTOKINES TNF-ALPHA LEVELS IN DIABETIC ALBINO WISTAR RAT MODEL. PJP [Internet]. 31Mar.2019 [cited 19May2019];15(1):3-. Available from: http://pjp.pps.org.pk/index.php/PJP/article/view/1072